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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C., is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [9,14]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [4].



GC-1 (Guanylyl cyclase, α1β1) C Show summary » More detailed page

GC-2 (Guanylyl cyclase, α2β1) C Show summary » More detailed page

Receptors and Subunits

Guanylyl cyclase α1 subunit C Show summary »

Guanylyl cyclase α2 subunit C Show summary »

Guanylyl cyclase β1 subunit C Show summary »

Guanylyl cyclase β2 subunit C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Annie Beuve, Peter Brouckaert, John C. Burnett, Jr., Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Doris Koesling, Michaela Kuhn, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman. Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase. Accessed on 21/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.