Top ▲

Transmembrane guanylyl cyclases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


« Hide

Transmembrane guanylyl cyclases are homodimeric receptors activated by a diverse range of endogenous ligands. GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grüeneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors. Family members have conserved ligand-binding, catalytic (guanylyl cyclase) and regulatory domains with the exception of NPR-C which has an extracellular binding domain homologous to that of other NPRs, but with a truncated intracellular domain which appears to couple, via the Gi/o family of G proteins, to activation of phospholipase C, inwardly-rectifying potassium channels and inhibition of adenylyl cyclase activity [16].


GC-A (Guanylyl cyclase-A) C Show summary » More detailed page

GC-B (Guanylyl cyclase-B) C Show summary » More detailed page

GC-C (Guanylyl cyclase-C) C Show summary » More detailed page

NPR-C (natriuretic peptide receptor 3) C Show summary » More detailed page

GC-D (Guanylyl cyclase-D) C Show summary » More detailed page

GC-E (Guanylyl cyclase-E) C Show summary » More detailed page

GC-F (Guanylyl cyclase-F) C Show summary » More detailed page

GC-G (Guanylyl cyclase-G) C Show summary » More detailed page


Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Annie Beuve, Peter Brouckaert, John C. Burnett, Jr., Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Doris Koesling, Michaela Kuhn, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman. Transmembrane guanylyl cyclases. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Catalytic receptors. Br J Pharmacol. 174 Suppl 1: S225-S271.