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Transmembrane guanylyl cyclases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Transmembrane guanylyl cyclases are homodimeric receptors activated by a diverse range of endogenous ligands. GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grüeneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors. Family members have conserved ligand-binding, catalytic (guanylyl cyclase) and regulatory domains with the exception of NPR-C which has an extracellular binding domain homologous to that of other NPRs, but with a truncated intracellular domain which appears to couple, via the Gi/o family of G proteins, to activation of phospholipase C, inwardly-rectifying potassium channels and inhibition of adenylyl cyclase activity [19].


GC-A (Guanylyl cyclase-A) C Show summary » More detailed page

GC-B (Guanylyl cyclase-B) C Show summary » More detailed page

GC-C (Guanylyl cyclase-C) C Show summary » More detailed page

NPR-C (natriuretic peptide receptor 3) C Show summary » More detailed page

GC-D (Guanylyl cyclase-D) C Show summary » More detailed page

GC-E (Guanylyl cyclase-E) C Show summary » More detailed page

GC-F (Guanylyl cyclase-F) C Show summary » More detailed page

GC-G (Guanylyl cyclase-G) C Show summary » More detailed page


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.