natriuretic peptide receptor 3 | Transmembrane guanylyl cyclases | IUPHAR/BPS Guide to PHARMACOLOGY

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natriuretic peptide receptor 3

Target not currently curated in GtoImmuPdb

Target id: 1749

Nomenclature: natriuretic peptide receptor 3

Abbreviated Name: NPR-C

Family: Transmembrane guanylyl cyclases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NPR3 natriuretic peptide receptor 3
Mouse - - Npr3 natriuretic peptide receptor 3
Rat - - Npr3 natriuretic peptide receptor 3
Previous and Unofficial Names
ANP-C | ANP-CR | ANPR-C | Atrial natriuretic peptide clearence receptor 3 | atrial natriuretic peptide receptor 3 | atrial natriuretic peptide receptor type C | GUCY2B | lgj | longjohn | natriuretic peptide receptor-C | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | Nppc receptor | NPR3
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands
osteocrin {Sp: Human}
Potency order (Human)
atrial natriuretic peptide (NPPA, P01160) > C-type natriuretic peptide (NPPC, P23582) ≥ brain natriuretic peptide (NPPB, P16860)  [5]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PL-3994 Hs Agonist 8.1 pKi 1
pKi 8.1 (Ki 7x10-9 M) [1]
cANF4-23 Hs Agonist - - 3
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AP811 Hs Binding 9.3 pKi 6
pKi 9.3 (Ki 5x10-10 M) [6]
M372049 Hs Antagonist - - 2
osteocrin {Sp: Human} Hs Antagonist - - 4
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]ANP (human) Hs - - -


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1. Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW et al.. (2013) In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther, 26 (2): 229-38. [PMID:23154072]

2. Hobbs A, Foster P, Prescott C, Scotland R, Ahluwalia A. (2004) Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation, 110 (10): 1231-5. [PMID:15337698]

3. Maack T, Suzuki M, Almeida FA, Nussenzveig D, Scarborough RM, McEnroe GA, Lewicki JA. (1987) Physiological role of silent receptors of atrial natriuretic factor. Science, 238 (4827): 675-8. [PMID:2823385]

4. Moffatt P, Thomas G, Sellin K, Bessette MC, Lafrenière F, Akhouayri O, St-Arnaud R, Lanctôt C. (2007) Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. J. Biol. Chem., 282 (50): 36454-62. [PMID:17951249]

5. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]

6. Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR, Dantzman CL, Edwards PD, Jacobs RT et al.. (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg. Med. Chem. Lett., 10 (17): 1949-52. [PMID:10987424]


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