Guanylyl cyclase-B | Transmembrane guanylyl cyclases | IUPHAR/BPS Guide to PHARMACOLOGY

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Guanylyl cyclase-B

Target not currently curated in GtoImmuPdb

Target id: 1748

Nomenclature: Guanylyl cyclase-B

Abbreviated Name: GC-B

Family: Transmembrane guanylyl cyclases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NPR2 natriuretic peptide receptor 2
Mouse - - Npr2 natriuretic peptide receptor 2
Rat - - Npr2 natriuretic peptide receptor 2
Previous and Unofficial Names
ANPB receptor | natriuretic peptide receptor 2 | ANP-B | ANPR-B | atrial natriuretic peptide receptor 2 | atrial natriuretic peptide receptor B | guanylate cyclase B | atrionatriuretic peptide receptor B | natriuretic peptide receptor-B
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands
C-type natriuretic peptide {Sp: Human}
Potency order (Human)
C-type natriuretic peptide (NPPC, P23582) >> atrial natriuretic peptide (NPPA, P01160) >> brain natriuretic peptide (NPPB, P16860)  [6]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cenderitide Hs Agonist - - 4
vosoritide Hs Agonist - - 3
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
peptide P19 [PMID: 15652659] Hs Antagonist 7.8 pKd 2
pKd 7.8 [2]
HS-142-1 Hs Antagonist - - 5
compound C10 [PMID: 24297249] Hs Antagonist - - 1
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IEP


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1. Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO. (2014) Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch. Pharmacol., 387 (1): 5-14. [PMID:24297249]

2. Deschênes J, Duperé C, McNicoll N, L'Heureux N, Auger F, Fournier A, De Léan A. (2005) Development of a selective peptide antagonist for the human natriuretic peptide receptor-B. Peptides, 26 (3): 517-24. [PMID:15652659]

3. Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ, Bell SM, Bullens S, Bunting S et al.. (2012) Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am. J. Hum. Genet., 91 (6): 1108-14. [PMID:23200862]

4. Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett Jr JC. (2012) CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS ONE, 7 (12): e52422. [PMID:23272242]

5. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem. Biophys. Res. Commun., 176 (3): 949-57. [PMID:1674870]

6. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]


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