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Target not currently curated in GtoImmuPdb
Target id: 2031
Nomenclature: Guanylyl cyclase-E
Abbreviated Name: GC-E
Family: Transmembrane guanylyl cyclases
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 1103 | 17p13.1 | GUCY2D | guanylate cyclase 2D, retinal | |
| Mouse | 1 | 1108 | 11 42.51 cM | Gucy2e | guanylate cyclase 2e | |
| Rat | 1 | 1108 | 1q32 | Gucy2d | guanylate cyclase 2D, retinal | |
| Previous and Unofficial Names |
| cone rod dystrophy 5/6 | GUC1A4 | retGC | guanylate cyclase 2D, membrane (retina-specific) | Ret-GC-1 | guanylate cyclase 2D, retinal | Ret1-GC | guanylate cyclase 2D | Gucy2e | guanylate cyclase 2E |
| Database Links |
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| Alphafold | Q02846 (Hs), P52785 (Mm), P51840 (Rn) |
| CATH/Gene3D | 3.30.70.1230 |
| Ensembl Gene | ENSG00000132518 (Hs), ENSMUSG00000020890 (Mm), ENSRNOG00000007931 (Rn) |
| Entrez Gene | 3000 (Hs), 14919 (Mm), 113911 (Rn) |
| Human Protein Atlas | ENSG00000132518 (Hs) |
| KEGG Gene | hsa:3000 (Hs), mmu:14919 (Mm), rno:113911 (Rn) |
| OMIM | 600179 (Hs) |
| Orphanet | ORPHA122340 (Hs) |
| Pharos | Q02846 (Hs) |
| RefSeq Nucleotide | NM_000180 (Hs), NM_008192 (Mm), NM_130737 (Rn) |
| RefSeq Protein | NP_000171 (Hs), NP_032218 (Mm), NP_570093 (Rn) |
| UniProtKB | Q02846 (Hs), P52785 (Mm), P51840 (Rn) |
| Wikipedia | GUCY2D (Hs) |
| Natural/Endogenous Ligands |
| guanylyl cyclase-activating protein 1 {Sp: Human, Mouse, Rat} |
| guanylyl cyclase-activating protein 2 {Sp: Human, Mouse, Rat} |
| Localisation |
| Retinal photoreceptors |
| Principal function(s) |
| Vision/phototransduction |
Download all structure-activity data for this target as a CSV file 
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| Clinically-Relevant Mutations and Pathophysiology
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