Synonyms: compound 1 [PMID: 32910655] | TNO-155 | TNO155
Compound class:
Synthetic organic
Comment: TNO155 is an oral, allosteric inhibitor of SHP2 (a nonreceptor protein tyrosine phosphatase that's encoded by the PTPN11 gene) [1]. SHP2 is an oncoprotein in its own right, but its inhibition is also being exploited to combat tumours that are driven by hyperactivation in the RAS-RAF-ERK signalling pathway.
We matched TNO155's chemical structure to the INN 'batoprotafib' which was published in the WHO's proposed INN list 127 on 21 July 2022. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(3S,4S)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine |
International Nonproprietary Names ![]() |
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INN number | INN |
12347 | batoprotafib |
Synonyms ![]() |
compound 1 [PMID: 32910655] | TNO-155 | TNO155 |
Database Links ![]() |
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BindingDB Ligand | 50553783 |
CAS Registry No. | 1801765-04-7 (source: PubChem) |
ChEMBL Ligand | CHEMBL4650521 |
GtoPdb PubChem SID | 472319190 |
PubChem CID | 118238370 |
RCSB PDB Ligand | VKS, VKS |
Search Google for chemical match using the InChIKey | UCJZOKGUEJUNIO-IINYFYTJSA-N |
Search Google for chemicals with the same backbone | UCJZOKGUEJUNIO |
Search PubMed clinical trials | batoprotafib |
Search PubMed titles | batoprotafib |
Search PubMed titles/abstracts | batoprotafib |
UniChem Compound Search for chemical match using the InChIKey | UCJZOKGUEJUNIO-IINYFYTJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UCJZOKGUEJUNIO-IINYFYTJSA-N |
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Batoprotafib (links to external site)
Cat. No. HY-136173 |