ABT702 [Ligand Id: 5131] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL66089 (ABT-702) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263] | ||||||||
| ChEMBL | Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells. | F | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2001) 44: 2133-2138 [PMID:11405650] |
| ChEMBL | In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cells | B | 7.36 | pIC50 | 43.3 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2071-2074 [PMID:11514141] |
| ChEMBL | Inhibitory activity against human adenosine kinase expressed in Escherichia coli | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1997-2000 [PMID:15050645] |
| ChEMBL | Inhibition of adenosine kinase (unknown origin) | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2015) 95: 76-95 [PMID:25794791] |
| ChEMBL | Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMP | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2016) 59: 6860-6877 [PMID:27410258] |
| ChEMBL | Tested for inhibitory activity against AK in an in vitro cell-free enzyme assay | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2000) 43: 4781-4786 [PMID:11123986] |
| ChEMBL | Inhibitory concentration against adenosine kinase | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2004) 47: 3463-3482 [PMID:15214773] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 1156-64 [PMID:11082453] |
| ChEMBL | In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzyme | B | 8.89 | pIC50 | 1.3 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2071-2074 [PMID:11514141] |
| Adenosine kinase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384] [GtoPdb: 1231] [UniProtKB: Q64640] | ||||||||
| ChEMBL | Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assay | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 83-86 [PMID:11140740] |
| ChEMBL | Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 83-86 [PMID:11140740] |
| ChEMBL | In vitro inhibition of Adenosine kinase (AK) | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2001) 44: 2133-2138 [PMID:11405650] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
