ABT702 [Ligand Id: 5131] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL66089 (ABT-702)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells. F 7.3 pIC50 50 nM IC50 J. Med. Chem. (2001) 44: 2133-2138 [PMID:11405650]
ChEMBL In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cells B 7.36 pIC50 43.3 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2071-2074 [PMID:11514141]
ChEMBL Inhibitory activity against human adenosine kinase expressed in Escherichia coli B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 1997-2000 [PMID:15050645]
ChEMBL Inhibition of adenosine kinase (unknown origin) B 8.7 pIC50 2 nM IC50 Eur. J. Med. Chem. (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMP B 8.77 pIC50 1.7 nM IC50 J Med Chem (2016) 59: 6860-6877 [PMID:27410258]
ChEMBL Tested for inhibitory activity against AK in an in vitro cell-free enzyme assay B 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2000) 43: 4781-4786 [PMID:11123986]
ChEMBL Inhibitory concentration against adenosine kinase B 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2004) 47: 3463-3482 [PMID:15214773]
GtoPdb - - 8.8 pIC50 1.58 nM IC50 J Pharmacol Exp Ther (2000) 295: 1156-64 [PMID:11082453]
ChEMBL In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzyme B 8.89 pIC50 1.3 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2071-2074 [PMID:11514141]
Adenosine kinase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384] [GtoPdb: 1231] [UniProtKB: Q64640]
ChEMBL Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assay B 7.3 pIC50 50 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 83-86 [PMID:11140740]
ChEMBL Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 83-86 [PMID:11140740]
ChEMBL In vitro inhibition of Adenosine kinase (AK) B 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2001) 44: 2133-2138 [PMID:11405650]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]