ABT702 [Ligand Id: 5131] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL66089 (ABT-702)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells. F 7.3 pIC50 50 nM IC50 J Med Chem (2001) 44: 2133-2138 [PMID:11405650]
ChEMBL In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cells B 7.36 pIC50 43.3 nM IC50 Bioorg Med Chem Lett (2001) 11: 2071-2074 [PMID:11514141]
ChEMBL Inhibitory activity against human adenosine kinase expressed in Escherichia coli B 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2004) 14: 1997-2000 [PMID:15050645]
ChEMBL Inhibition of adenosine kinase (unknown origin) B 8.7 pIC50 2 nM IC50 Eur J Med Chem (2015) 95: 76-95 [PMID:25794791]
ChEMBL Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMP B 8.77 pIC50 1.7 nM IC50 J Med Chem (2016) 59: 6860-6877 [PMID:27410258]
ChEMBL Tested for inhibitory activity against AK in an in vitro cell-free enzyme assay B 8.77 pIC50 1.7 nM IC50 J Med Chem (2000) 43: 4781-4786 [PMID:11123986]
ChEMBL Inhibitory concentration against adenosine kinase B 8.77 pIC50 1.7 nM IC50 J Med Chem (2004) 47: 3463-3482 [PMID:15214773]
GtoPdb - - 8.8 pIC50 1.58 nM IC50 J Pharmacol Exp Ther (2000) 295: 1156-64 [PMID:11082453]
ChEMBL In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzyme B 8.89 pIC50 1.3 nM IC50 Bioorg Med Chem Lett (2001) 11: 2071-2074 [PMID:11514141]
Adenosine kinase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384] [GtoPdb: 1231] [UniProtKB: Q64640]
ChEMBL Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assay B 7.3 pIC50 50 nM IC50 Bioorg Med Chem Lett (2001) 11: 83-86 [PMID:11140740]
ChEMBL Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay B 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2001) 11: 83-86 [PMID:11140740]
ChEMBL In vitro inhibition of Adenosine kinase (AK) B 8.77 pIC50 1.7 nM IC50 J Med Chem (2001) 44: 2133-2138 [PMID:11405650]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]