QO-58 [Ligand Id: 7669] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1689654
  • Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human [ChEMBL: CHEMBL2221348] [GtoPdb: 562561] [UniProtKB: O43525O43526]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221348] [GtoPdb: 562561] [UniProtKB: O43525O43526]
GtoPdb - - 6.3 pEC50 - - - Br J Pharmacol (2013) 168: 1030-42 [PMID:23013484]
ChEMBL Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay B 7.22 pEC50 60 nM EC50 Eur. J. Med. Chem. (2011) 46: 934-943 [PMID:21296466]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]