β-alanine [Ligand Id: 2365] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL297569 (3-Amino-Propionic Acid, Beta-Alanine)
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  • GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439]
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  • Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
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  • MRGPRD in Human [GtoPdb: 152] [UniProtKB: Q8TDS7]
  • MRGPRD in Mouse [GtoPdb: 152] [UniProtKB: Q91ZB8]
  • MRGPRD in Rat [GtoPdb: 152] [UniProtKB: Q7TN41]
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  • Glycine Receptor (All subtypes) in Human [GtoPdb: 428]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GAT2/GABA transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4535] [GtoPdb: 930] [UniProtKB: Q9NSD5]
ChEMBL Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4 pIC50 >100000 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
GAT3/GABA transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5208] [GtoPdb: 931] [UniProtKB: P48066]
ChEMBL Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.39 pIC50 41200 nM IC50 Bioorg. Med. Chem. (2013) 21: 4938-4950 [PMID:23886812]
ChEMBL Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis B 4.39 pIC50 41200 nM IC50 ACS Med. Chem. Lett. (2014) 5: 889-893 [PMID:25147609]
GAT2/GABA transporter 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5205] [GtoPdb: 930] [UniProtKB: P31649]
ChEMBL Inhibition of mouse GTA 3 receptor B 4.18 pIC50 66069.34 nM IC50 Eur J Med Chem (2020) 188: 111920-111920 [PMID:31901745]
ChEMBL Inhibition of GABA uptake at murine GAT-2 expressed in HEK293 cells B 4.66 pIC50 21877.62 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
GAT3/GABA transporter 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3699] [GtoPdb: 931] [UniProtKB: P31650]
ChEMBL Inhibition of GABA uptake at murine GAT-3 expressed in HEK293 cells B 4.46 pIC50 34673.69 nM IC50 Eur. J. Med. Chem. (2013) 65: 487-499 [PMID:23770450]
ChEMBL Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells B 4.66 pIC50 21877.62 nM IC50 Eur. J. Med. Chem. (2011) 46: 1483-1498 [PMID:21353350]
GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439]
ChEMBL Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes. B 4.94 pIC50 11600 nM IC50 J. Med. Chem. (1992) 35: 233-241 [PMID:1310117]
Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8]
ChEMBL Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting B 0.38 pKi -0.38 mM pKi Bioorg. Med. Chem. (2011) 19: 6409-6418 [PMID:21955456]
MRGPRD in Human [GtoPdb: 152] [UniProtKB: Q8TDS7]
GtoPdb - - 4.8 pEC50 15000 nM EC50 J Biol Chem (2004) 279: 23559-64 [PMID:15037633];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
MRGPRD in Mouse [GtoPdb: 152] [UniProtKB: Q91ZB8]
GtoPdb - - 4.36 pEC50 44000 nM EC50 J Biol Chem (2004) 279: 23559-64 [PMID:15037633]
MRGPRD in Rat [GtoPdb: 152] [UniProtKB: Q7TN41]
GtoPdb - - 4.85 pEC50 14000 nM EC50 J Biol Chem (2004) 279: 23559-64 [PMID:15037633]
Glycine Receptor (All subtypes) in Human [GtoPdb: 428]
GtoPdb - - 4.3 pEC50 - - - EMBO J (1997) 16: 110-20 [PMID:9009272]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]