β-alanine [Ligand Id: 2365] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL297569 (3-Amino-Propionic Acid, Beta-Alanine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GAT2/GABA transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4535] [GtoPdb: 930] [UniProtKB: Q9NSD5] | ||||||||
| ChEMBL | Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4 | pIC50 | >100000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 889-893 [PMID:25147609] |
| GAT3/GABA transporter 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5208] [GtoPdb: 931] [UniProtKB: P48066] | ||||||||
| ChEMBL | Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4.39 | pIC50 | 41200 | nM | IC50 | Bioorg Med Chem (2013) 21: 4938-4950 [PMID:23886812] |
| ChEMBL | Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | B | 4.39 | pIC50 | 41200 | nM | IC50 | ACS Med Chem Lett (2014) 5: 889-893 [PMID:25147609] |
| GAT2/GABA transporter 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5205] [GtoPdb: 930] [UniProtKB: P31649] | ||||||||
| ChEMBL | Inhibition of mouse GTA 3 receptor | B | 4.18 | pIC50 | 66069.34 | nM | IC50 | Eur J Med Chem (2020) 188: 111920-111920 [PMID:31901745] |
| ChEMBL | Inhibition of GABA uptake at murine GAT-2 expressed in HEK293 cells | B | 4.66 | pIC50 | 21877.62 | nM | IC50 | Eur J Med Chem (2013) 65: 487-499 [PMID:23770450] |
| GAT3/GABA transporter 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3699] [GtoPdb: 931] [UniProtKB: P31650] | ||||||||
| ChEMBL | Inhibition of GABA uptake at murine GAT-3 expressed in HEK293 cells | B | 4.46 | pIC50 | 34673.69 | nM | IC50 | Eur J Med Chem (2013) 65: 487-499 [PMID:23770450] |
| ChEMBL | Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells | B | 4.66 | pIC50 | 21877.62 | nM | IC50 | Eur J Med Chem (2011) 46: 1483-1498 [PMID:21353350] |
| GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439] | ||||||||
| ChEMBL | Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes. | B | 4.94 | pIC50 | 11600 | nM | IC50 | J Med Chem (1992) 35: 233-241 [PMID:1310117] |
| Proton-coupled Amino acid Transporter 1/Proton-coupled amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914279] [GtoPdb: 1161] [UniProtKB: Q7Z2H8] | ||||||||
| ChEMBL | Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting | B | 0.38 | pKi | -0.38 | mM | pKi | Bioorg Med Chem (2011) 19: 6409-6418 [PMID:21955456] |
| MRGPRD in Human [GtoPdb: 152] [UniProtKB: Q8TDS7] | ||||||||
| GtoPdb | - | - | 4.8 | pEC50 | 15000 | nM | EC50 |
J Biol Chem (2004) 279: 23559-64 [PMID:15037633]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314] |
| MRGPRD in Mouse [GtoPdb: 152] [UniProtKB: Q91ZB8] | ||||||||
| GtoPdb | - | - | 4.36 | pEC50 | 44000 | nM | EC50 | J Biol Chem (2004) 279: 23559-64 [PMID:15037633] |
| MRGPRD in Rat [GtoPdb: 152] [UniProtKB: Q7TN41] | ||||||||
| GtoPdb | - | - | 4.85 | pEC50 | 14000 | nM | EC50 | J Biol Chem (2004) 279: 23559-64 [PMID:15037633] |
| Glycine Receptor (All subtypes) in Human [GtoPdb: 428] | ||||||||
| GtoPdb | - | - | 4.3 | pEC50 | - | - | - | EMBO J (1997) 16: 110-20 [PMID:9009272] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
