ChEMBL ligand: CHEMBL12998 (L-755507)
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] This target only has 1 pki data point 6.24 1 CHEMBL12998_lig_chart_1 Beta-1 adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] This target only has 1 pki data point 6.8 2 CHEMBL12998_lig_chart_2 Beta-2 adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] This target only has 0 pki data point 0 3 CHEMBL12998_lig_chart_3 Beta-3 adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
Cruzipain in Trypanosoma cruzi [ChEMBL: CHEMBL3563] [UniProtKB: P25779] This target only has 0 pki data point 0 4 CHEMBL12998_lig_chart_4 Cruzipain Trypanosoma cruzi There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Inhibition of I-iodocyanopindolol binding to human beta 1 adrenergic receptors	B	6.24	pKi	570	nM	Ki	J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
ChEMBL	In vitro affinity at Beta-1 adrenergic receptor in the presence of [125I]iodocyanopindolol.	B	6.7	pIC50	200	nM	IC50	Bioorg. Med. Chem. Lett. (1998) 8: 1107-1112 [PMID:9871717]
ChEMBL	In vitro activity to increase cAMP levels in Chinese hamster ovary (CHO) cells expressing the cloned human beta 1 Adrenergic receptor	B	6.48	pEC50	330	nM	EC50	J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Inhibition of I-iodocyanopindolol binding to human beta 2 adrenergic receptors	B	6.8	pKi	160	nM	Ki	J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
ChEMBL	Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol	B	5.52	pIC50	3000	nM	IC50	Bioorg. Med. Chem. Lett. (1998) 8: 3087-3092 [PMID:9873681]
ChEMBL	In vitro affinity at Beta-2 adrenergic receptor in the presence of [125I]iodocyanopindolol.	B	6.72	pIC50	190	nM	IC50	Bioorg. Med. Chem. Lett. (1998) 8: 1107-1112 [PMID:9871717]
ChEMBL	Increased cAMP levels of Chinese hamster ovary (CHO) cells expressing human beta 2 adrenergic receptors	F	7.7	pEC50	20	nM	EC50	J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL	In vitro increase in cAMP levels in Chinese hamster ovary cells expressing the human cloned beta 3 Adrenergic receptor.	F	9	pEC50	1	nM	EC50	J. Med. Chem. (2001) 44: 1456-1466 [PMID:11311069]
ChEMBL	Evaluated for its agonist activity against human Beta-3 adrenergic receptor	F	9.37	pEC50	0.43	nM	EC50	Bioorg. Med. Chem. Lett. (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL	Agonism against Beta-3 adrenergic receptor	F	9.37	pEC50	0.43	nM	EC50	Bioorg. Med. Chem. Lett. (1998) 8: 3087-3092 [PMID:9873681]
ChEMBL	Agonist activity towards human Beta-3 adrenergic receptor	F	9.37	pEC50	0.43	nM	EC50	Bioorg. Med. Chem. Lett. (1998) 8: 1107-1112 [PMID:9871717]
ChEMBL	Binding affinity towards human Beta-3 adrenergic receptor	B	9.37	pEC50	0.43	nM	EC50	J. Med. Chem. (1999) 42: 181-201 [PMID:9925722]
GtoPdb	-	-	10.1	pEC50	-	-	-	Br J Pharmacol (2010) 160: 1048-61 [PMID:20590599]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL	Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening	B	4.22	pIC50	>60000	nM	IC50	J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]
ChEMBL	Inhibition of Trypanosoma cruzi cruzain by Flexstation microplate spectrofluorimetry	B	4.92	pIC50	12000	nM	IC50	J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]