ChEMBL ligand: CHEMBL42126 (Piclamilast, RP-73041, RP 73401, RP-73401, RP73401, RPR-73401)
phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815] Phosphodiesterase 4A in Pig [ChEMBL: CHEMBL3333] [UniProtKB: O77823] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4B/Phosphodiesterase 4B in Human [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4C/Phosphodiesterase 4C in Human [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
GtoPdb	Inhibition of rolipram binding to human PDE4	-	8.82	pKi	1.5	nM	Ki	J Med Chem (1994) 37: 1696-703 [PMID:8201604]
ChEMBL	Inhibition of human recombinant PDE4A	B	8.4	pIC50	4	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).	B	8.8	pIC50	1.6	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
Phosphodiesterase 4A in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3333] [UniProtKB: O77823]
ChEMBL	Inhibitory potency against pig aortic PDE IV	B	9	pIC50	1	nM	IC50	J Med Chem (1994) 37: 1696-1703 [PMID:8201604]
phosphodiesterase 4B/Phosphodiesterase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL275] [GtoPdb: 1301] [UniProtKB: Q07343]
ChEMBL	Inhibition of human recombinant PDE4B	B	8.52	pIC50	3	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hr	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2010) 20: 2928-2932 [PMID:20378348]
ChEMBL	Inhibition of recombinant human Phosphodiesterase 4B	B	9	pIC50	1	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
ChEMBL	Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytes	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem Lett (2002) 12: 653-658 [PMID:11844693]
ChEMBL	Inhibition of human PDE4B	B	10.39	pIC50	0.04	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	10.39	pIC50	0.04	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4B by scintillation counting method	B	10.39	pIC50	0.04	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
phosphodiesterase 4C/Phosphodiesterase 4C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL291] [GtoPdb: 1302] [UniProtKB: Q08493]
ChEMBL	Inhibition of human recombinant PDE4C	B	7.85	pIC50	14	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4C	B	8.42	pIC50	3.8	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL	Inhibition of human recombinant PDE4D	B	8.7	pIC50	2	nM	IC50	J Med Chem (2007) 50: 344-349 [PMID:17228876]
ChEMBL	In vitro inhibitory activity on unpurified recombinant Phosphodiesterase 4D	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (1998) 41: 266-270 [PMID:9464356]
ChEMBL	Inhibition of human PDE4D	B	10.68	pIC50	0.02	nM	IC50	Bioorg Med Chem (2010) 18: 2204-2218 [PMID:20188577]
ChEMBL	Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method	B	10.68	pIC50	0.02	nM	IC50	J Med Chem (2016) 59: 7029-7065 [PMID:26908025]
ChEMBL	Inhibition of human PDE4D by scintillation counting method	B	10.68	pIC50	0.02	nM	IC50	J Med Chem (2020) 63: 10594-10617 [PMID:32255344]
ChEMBL	Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method	B	10.7	pIC50	0.02	nM	IC50	EP-2674161-A1. FMO3 inhibitors for treating pain (null)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]