ChEMBL ligand: CHEMBL434024
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	7.23	pKi	59.3	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	7.23	pKi	59.3	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	7.85	pKi	14	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	9.13	pKi	0.74	nM	Ki	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	9.13	pKi	0.74	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.46	pIC50	349.1	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	6.46	pIC50	349.1	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	6.85	pIC50	141.25	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	6.85	pIC50	140	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	8.04	pIC50	9.2	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
GtoPdb	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	-	8.04	pIC50	9.2	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
ChEMBL	Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting	B	8.4	pIC50	4	nM	IC50	J Med Chem (2018) 61: 6904-6917 [PMID:30016091]
ChEMBL	Inhibition of human FPPS expressed in Escherichia coli BL21 (DE3) preincubated for 10 mins in presence compound relative to control	B	8.4	pIC50	4	nM	IC50	J Med Chem (2022) 65: 2471-2496 [PMID:35077178]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]