relcovaptan [Ligand Id: 2200] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL419667 (Relcovaptan, Sr-49059, SR 49059, SR49059, TDI 0134, TDI-0134) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| ChEMBL | Binding affinity to vasopressin V1a receptor | B | 8.7 | pKi | 2 | nM | Ki | J Nat Prod (1994) 57: 1329-1335 [PMID:7807119] |
| ChEMBL | Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 384-well plate membranes | B | 8.83 | pKi | 1.48 | nM | Ki | J Med Chem (2007) 50: 4976-4985 [PMID:17850055] |
| ChEMBL | Displacement of [Se-Se]-AVP from human V1A receptor expressed in CHO cells after 4 hrs by RP-LC-ICPMS analysis | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2018) 61: 10173-10184 [PMID:30395477] |
| ChEMBL | Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate cells | B | 9.07 | pKi | 0.85 | nM | Ki | J Med Chem (2007) 50: 4976-4985 [PMID:17850055] |
| ChEMBL | Inhibition of human vasopressin V1a receptor expressed in CHO cells by polarisation binding assay using 96-well plate membranes | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (2007) 50: 4976-4985 [PMID:17850055] |
| ChEMBL | Binding affinity at cloned human Vasopressin V1a receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| ChEMBL | Displacement of [125I]OH-Phpa-LVA from human V1A receptor expressed in CHO cells after 4 hrs by gamma counter analysis | B | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2018) 61: 10173-10184 [PMID:30395477] |
| ChEMBL | Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 384-well plate membranes | B | 9.28 | pKi | 0.52 | nM | Ki | J Med Chem (2007) 50: 4976-4985 [PMID:17850055] |
| GtoPdb | - | - | 9.3 | pKi | - | - | - |
J Biol Chem (1994) 269: 3304-10 [PMID:8106369]; Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Eur J Biochem (2000) 267: 4253-63 [PMID:10866830]; Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; Br J Pharmacol (2005) 146: 744-751 [PMID:16158071] |
| ChEMBL | Inhibition of human vasopressin V1a receptor expressed in COS7 cells by HTRF-FRET assay using 96-well plate membranes | B | 9.72 | pKi | 0.19 | nM | Ki | J Med Chem (2007) 50: 4976-4985 [PMID:17850055] |
| ChEMBL | Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 5684-5687 [PMID:21885275] |
| V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] | ||||||||
| ChEMBL | Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver | B | 8.84 | pKi | 1.43 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518] | ||||||||
| ChEMBL | Binding affinity at cloned human Vasopressin V2 receptor stably expressed in CHO cells, using [3H]AVP as radioligand | B | 6.75 | pKi | 178 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - |
Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Endocrinology (1997) 138: 4109-22 [PMID:9322919]; Eur J Biochem (2000) 267: 4253-63 [PMID:10866830]; Br J Pharmacol (2001) 133: 746-54 [PMID:11429400]; Kidney Int (2000) 58: 1613-22 [PMID:11012895] |
| V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
| ChEMBL | Binding affinity at Vasopressin V2 receptor, performed using [3H]AVP on rat kidney | B | 6.55 | pKi | 285 | nM | Ki | J Med Chem (2002) 45: 2589-2598 [PMID:12036368] |
| V1B receptor in Human [GtoPdb: 367] [UniProtKB: P47901] | ||||||||
| GtoPdb | - | - | 7.3 | pKi | - | - | - |
Br J Pharmacol (1998) 125: 1463-70 [PMID:9884074]; Endocrinology (1997) 138: 4109-22 [PMID:9322919]; Br J Pharmacol (2001) 133: 746-54 [PMID:11429400]; Br J Pharmacol (2005) 146: 744-751 [PMID:16158071] |
| OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - |
Br J Obstet Gynaecol (1999) 106: 1047-53 [PMID:10519430]; Br J Pharmacol (2005) 146: 744-751 [PMID:16158071] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
