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ChEMBL ligand: CHEMBL2381669 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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kallikrein related peptidase 3/Prostate specific antigen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2099] [GtoPdb: 2373] [UniProtKB: P07288] | ||||||||
ChEMBL | Inhibition of PSA (unknown origin) in RPMI in presence of 1% fetal bovine serum, 1% penicillin/streptomycin, 1% L-glutamine | B | 6.16 | pKi | 699 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
ChEMBL | Inhibition of PSA (unknown origin) in female plasma | B | 6.22 | pKi | 604 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
ChEMBL | Inhibition of PSA (unknown origin) in RPMI in presence of 1% fetal bovine serum | B | 6.85 | pKi | 142 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
ChEMBL | Inhibition of PSA (unknown origin) in RPMI | B | 7.12 | pKi | 75 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
GtoPdb | PSA isolated from human seminal plasma. | - | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2013) 56: 4224-35 [PMID:23692593] |
ChEMBL | Inhibition of human seminal fluid PSA using Mu-SRKSQQY-AMC as substrate measured for 30 mins by fluorescence assay | B | 7.14 | pKi | 72.29 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
ChEMBL | Inhibition of PSA (unknown origin) in 50 mM TRIS.HCL and 100 mM NaCl buffer at pH 7.8 | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2013) 56: 4224-4235 [PMID:23692593] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]