tanomastat [Ligand Id: 6468] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL261932 (BAY 12-9566, BAY-129566, BAY-12-9566, Tanomastat)
  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Inhibition of matrix metalloprotease-1 (MMP-1). B 5.3 pKi 5000 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay B 5.3 pIC50 >5000 nM IC50 J Med Chem (2002) 45: 219-232 [PMID:11754593]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of matrix metalloprotease-13 (MMP-13). B 5.83 pKi 1470 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of matrix metalloprotease-2 (MMP-2). B 7.96 pKi 11 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
GtoPdb - - 8 pKi 10 nM Ki Cancer Metastasis Rev (2006) 25: 115-36 [PMID:16680577]
ChEMBL In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay B 7.96 pIC50 11 nM IC50 J Med Chem (2002) 45: 219-232 [PMID:11754593]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of matrix metalloprotease-3 (MMP-3). B 6.84 pKi 143 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assay B 6.87 pIC50 134 nM IC50 J Med Chem (2002) 45: 219-232 [PMID:11754593]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of matrix metalloprotease-9 (MMP-9). B 6.52 pKi 301 nM Ki J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay B 6.52 pIC50 301 nM IC50 J Med Chem (2002) 45: 219-232 [PMID:11754593]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]