ChEMBL ligand: CHEMBL261932 (BAY 12-9566, BAY-12-9566, BAY-129566, Tanomastat)
MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] There should be some charts here, you may need to enable JavaScript!
MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] There should be some charts here, you may need to enable JavaScript!
MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] There should be some charts here, you may need to enable JavaScript!
MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] There should be some charts here, you may need to enable JavaScript!
MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL	Inhibition of matrix metalloprotease-1 (MMP-1).	B	5.3	pKi	5000	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of MMP-1 (unknown origin) assessed as inhibition constant	B	5.3	pKi	>5000	nM	Ki	Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437]
ChEMBL	In vitro selective inhibition against matrix metalloprotease-1 (MMP-1) using a fluorimetric assay	B	5.3	pIC50	>5000	nM	IC50	J Med Chem (2002) 45: 219-232 [PMID:11754593]
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL	Inhibition of matrix metalloprotease-13 (MMP-13).	B	5.83	pKi	1470	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of MMP-13 (unknown origin) assessed as inhibition constant	B	5.83	pKi	1470	nM	Ki	Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL	Inhibition of matrix metalloprotease-2 (MMP-2).	B	7.96	pKi	11	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of MMP-2 (unknown origin) assessed as inhibition constant	B	7.96	pKi	11	nM	Ki	Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437]
GtoPdb	-	-	8	pKi	10	nM	Ki	Cancer Metastasis Rev (2006) 25: 115-36 [PMID:16680577]
ChEMBL	In vitro selective inhibition against matrix metalloprotease-2 (MMP-2) using fluorimetric assay	B	7.96	pIC50	11	nM	IC50	J Med Chem (2002) 45: 219-232 [PMID:11754593]
ChEMBL	Inhibition of MMP-2 (unknown origin)	B	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2020) 194: 112260-112260 [PMID:32224379]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL	Inhibition of matrix metalloprotease-3 (MMP-3).	B	6.84	pKi	143	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of MMP-3 (unknown origin) assessed as inhibition constant	B	6.87	pKi	134	nM	Ki	Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437]
ChEMBL	Inhibition of Matrix metalloprotease-3 (MMP-3) in fluorimetric assay	B	6.87	pIC50	134	nM	IC50	J Med Chem (2002) 45: 219-232 [PMID:11754593]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL	Inhibition of matrix metalloprotease-9 (MMP-9).	B	6.52	pKi	301	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of MMP-9 (unknown origin) assessed as inhibition constant	B	6.52	pKi	301	nM	Ki	Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437]
ChEMBL	In vitro selective inhibition against Matrix metalloprotease-9 (MMP-9) using fluorimetric assay	B	6.52	pIC50	301	nM	IC50	J Med Chem (2002) 45: 219-232 [PMID:11754593]
ChEMBL	Inhibition of MMP-9 (unknown origin)	B	6.52	pIC50	301	nM	IC50	Eur J Med Chem (2020) 194: 112260-112260 [PMID:32224379]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]