ChEMBL ligand: CHEMBL3113165 (ML-355, ML355, Vlx-1005, VLX-1005)
12S-LOX/Arachidonate 12-lipoxygenase in Human [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] 12S-LOX/Arachidonate 12-lipoxygenase in Mouse [ChEMBL: CHEMBL3225] [GtoPdb: 1387] [UniProtKB: P39655] There should be some charts here, you may need to enable JavaScript!
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
ChEMBL	Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Michaelis Menten equation analysis	B	6.14	pKi	720	nM	Ki	J Med Chem (2014) 57: 495-506 [PMID:24393039]
ChEMBL	Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Michaelis Menten equation analysis	B	6.46	pKi	350	nM	Ki	J Med Chem (2014) 57: 495-506 [PMID:24393039]
ChEMBL	Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysis	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2021) 46: 116347-116347 [PMID:34507163]
ChEMBL	Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	6.47	pIC50	340	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
GtoPdb	-	-	6.47	pIC50	340	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
12S-LOX/Arachidonate 12-lipoxygenase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3225] [GtoPdb: 1387] [UniProtKB: P39655]
ChEMBL	Inhibition of 12-LOX in mouse BTC3 cells assessed as inhibition of arachidonic acid/calcium ionophore-induced 12-HETE production after 4 hrs by ELISA	B	6	pIC50	1000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	5.01	pIC50	9700	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL	Inhibition of N-terminal His6-tagged human epithelial 15-LOX2 using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human 5-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis	B	4	pIC50	>100000	nM	IC50	J Med Chem (2014) 57: 495-506 [PMID:24393039]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]