xylometazoline [Ligand Id: 517] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL312448 (Xylometazoline)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity towards human Alpha-1 adrenergic receptor B 7.04 pKi 91 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 4697-4699 [PMID:15324890]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand B 7.85 pKi 14 nM Ki J. Med. Chem. (1998) 41: 2243-2251 [PMID:9632357]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 1B receptor B 7.89 pKi 13 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 4697-4699 [PMID:15324890]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand B 9.15 pKi 0.7 nM Ki J. Med. Chem. (1998) 41: 2243-2251 [PMID:9632357]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 1D receptor B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 4697-4699 [PMID:15324890]
ChEMBL Tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV) F 6.43 pEC50 369 nM EC50 J. Med. Chem. (1998) 41: 2243-2251 [PMID:9632357]
α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944]
GtoPdb - - 6 pKi - - - Mol Pharmacol (1994) 46: 929-36 [PMID:7969082]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]