ChEMBL ligand: CHEMBL4570969
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum histone acetyltransferase GCN5 in Plasmodium falciparum [GtoPdb: 3191] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
ChEMBL	Binding affinity to human PCAF bromodomain by isothermal titration calorimetry	B	6.9	pKd	126	nM	Kd	J Med Chem (2019) 62: 4526-4542 [PMID:30998845]
ChEMBL	Inhibition of biotinylated peptide binding to human GST-tagged PCAF bromodomain expressed in Escherichia coli Rosetta (DE3) measured after 15 hrs by HTRF assay	B	7.44	pIC50	36	nM	IC50	J Med Chem (2019) 62: 4526-4542 [PMID:30998845]
Plasmodium falciparum histone acetyltransferase GCN5 in Plasmodium falciparum [GtoPdb: 3191]
GtoPdb	Isothermal titration calorimetry.	-	6.55	pKd	280	nM	Kd	Angew Chem Int Ed Engl (2017) 56: 827-831 [PMID:27966810]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]