Synonyms: compound 13 [PMID: 30525597] | MD222
Compound class:
Synthetic organic
Comment: MD-222 is a proteolysis targeting chimera (PROTAC) agent that induces degradation of the human murine double minute 2 (MDM2) protein [1]. MDM2 is a crucial cellular inhibitor of the tumour suppressor p53, and is an oncology drug target. MD-222 simultaneously binds to MDM2 and cereblon, bringing the target protein into the proximity of the ubiquitination zone of the E3 ligase.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms |
compound 13 [PMID: 30525597] | MD222 |
Database Links | |
BindingDB Ligand | 50505629 |
ChEMBL Ligand | CHEMBL4436772 |
GtoPdb PubChem SID | 458923760 |
PubChem CID | 131988640 |
Search Google for chemical match using the InChIKey | RRSNDVCODIMOFX-MPKOGUQCSA-N |
Search Google for chemicals with the same backbone | RRSNDVCODIMOFX |
UniChem Compound Search for chemical match using the InChIKey | RRSNDVCODIMOFX-MPKOGUQCSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RRSNDVCODIMOFX-MPKOGUQCSA-N |