(S)-UH 301 [Ligand Id: 61] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL22778 (UH-301)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity was measured on cloned Human D2A Receptor which is labeled by [3H]raclopride B 5.42 pKi 3760 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Binding affinity was evaluated against Dopamine receptor D2 on rat striatum using [3H]spiperone as radioligand; ND = Not determined B 6.21 pKi 614 nM Ki J Med Chem (1998) 41: 2765-2778 [PMID:9667967]
ChEMBL In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone B 6.21 pKi 614 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL In vitro radioligand binding assay on Dopamine receptor D2 of rat striatum using [3H]- spiperone B 6.4 pKi 400 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 7.6 pKd 25.12 nM Kd J Med Chem (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT B 7.06 pKi 87 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]
GtoPdb - - 7.9 pKi 13.5 nM Ki Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor sites, in rat striatum membranes using [3H]- sandoz 205-501 as radioligand B 6.4 pKi 400 nM Ki J Med Chem (1990) 33: 1541-1544 [PMID:2140413]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor sites in cortical membranes using [3H]8-OH-DPAT as radioligand B 7.28 pKi 52 nM Ki J Med Chem (1990) 33: 1541-1544 [PMID:2140413]
ChEMBL Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor B 7.28 pKi 52 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL Binding affinity was evaluated against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]8-OH-DPAT as radioligand B 7.34 pKi 46 nM Ki J Med Chem (1998) 41: 2765-2778 [PMID:9667967]
ChEMBL Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor B 7.34 pKi 46 nM Ki J Med Chem (1997) 40: 1252-1257 [PMID:9111299]
ChEMBL Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand B 7.61 pKi 24.8 nM Ki J Med Chem (1996) 39: 4036-4043 [PMID:8831769]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT B 5.5 pKi 3180 nM Ki J Med Chem (2000) 43: 1339-1349 [PMID:10753471]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]