ChEMBL ligand: CHEMBL13470 (SNC-80)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI	F	6.2	pKd	629	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
GtoPdb	-	-	7.2	pKi	-	-	-	Eur J Pharmacol (1997) 326: 101-4 [PMID:9178661]; J Med Chem (1994) 37: 2125-8 [PMID:8035418]
ChEMBL	Binding affinity for delta opioid receptor	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2109-2112 [PMID:15080989]
ChEMBL	Displacement of [3H]deltorphine 2 from human delta opioid receptor expressed in CHOK1 cells	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem (2008) 16: 2870-2885 [PMID:18249546]
ChEMBL	Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptor	B	8.89	pKi	1.29	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Displacement of [3H]-deltorphine from human delta opioid receptor expressed in CHO-K1 cells by scintillation counting analysis	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2014) 57: 6845-6860 [PMID:25062506]
ChEMBL	Displacement of [3H]deltrophine from human delta opioid receptor expressed in CHO-K1 cells after 120 mins by liquid scintillation counting method	B	8.92	pKi	1.2	nM	Ki	Medchemcomm (2016) 7: 317-326
ChEMBL	Binding affinity was measured against mutated human Opioid receptor delta 1 (W248L)	B	7.31	pIC50	49.1	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding affinity was measured against cloned human Opioid receptor delta 1 (wild-type,Wt)	B	8.55	pIC50	2.85	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding inhibition of [3H]- -naltrindole (0.15 nM) to membranes in CHO cells expressing Opioid receptor delta 1	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand	B	8.88	pIC50	1.31	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.	B	8.88	pIC50	1.31	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]-p-DPDPE human cloned receptors.	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Agonistic activity towards opioid receptor delta 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate	F	6.12	pEC50	760	nM	EC50	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay	F	6.68	pEC50	210	nM	EC50	ACS Med Chem Lett (2019) 10: 450-456 [PMID:30996778]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	F	7.8	pEC50	15.7	nM	EC50	Bioorg Med Chem (2012) 20: 949-961 [PMID:22197670]
ChEMBL	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	F	7.8	pEC50	15.7	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2792-2795 [PMID:19362480]
ChEMBL	Agonist activity at human DOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assay	F	7.84	pEC50	14.4	nM	EC50	J Med Chem (2020) 63: 2673-2687 [PMID:31834798]
ChEMBL	Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	8	pEC50	10	nM	EC50	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Agonist activity at human DOR expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	F	8.12	pEC50	7.6	nM	EC50	ACS Med Chem Lett (2020) 11: 720-726 [PMID:32435376]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2009) 19: 2289-2294 [PMID:19282177]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assay	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2007) 17: 6516-6520 [PMID:17935988]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding	F	8.32	pEC50	4.8	nM	EC50	J Med Chem (2006) 49: 5635-5639 [PMID:16942039]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by scintillation counting	F	8.32	pEC50	4.8	nM	EC50	Bioorg Med Chem Lett (2012) 22: 7340-7344 [PMID:23142613]
ChEMBL	Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding assay.	F	8.44	pEC50	3.67	nM	EC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Agonist potency was measured using GTP gamma-[35S] binding assay	B	8.44	pEC50	3.67	nM	EC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human delta opioid receptor by [35S]GTPgammaS binding assay	F	8.52	pEC50	2.99	nM	EC50	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Agonist activity at human delta opioid receptor expressed in CHO cells assessed as [35S]-GTP[gammaS] binding	F	8.72	pEC50	1.9	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Agonist activity at human delta opioid receptor expressed in HEK293 cells by CellKey method	B	8.77	pEC50	1.7	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells	B	7.78	pKi	16.6	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
ChEMBL	Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligand	B	8.77	pKi	1.7	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain cerebellum membrane	B	8.98	pKi	1.04	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Displacement of [3H]DPDPE from mouse brain delta opioid receptor by scintillation counting analysis	B	9.15	pKi	0.71	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor	B	5.7	pIC50	>2000	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	6.19	pIC50	646.8	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	In vitro antagonist activity against Opioid receptor delta 1 in the presence of 30 nM naltrindole, in a mouse vas deferens assay	F	6.2	pIC50	634	nM	IC50	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor	B	7.25	pIC50	56.5	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	In vitro agonist activity for Opioid receptor delta 1 was determined in a mouse vas deferens assay	F	8.1	pIC50	8	nM	IC50	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum	B	8.19	pIC50	6.41	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6398-6401 [PMID:18990576]
ChEMBL	Displacement of [3H]DPDPE from delta opioid receptor in ICR mouse whole brain	B	8.19	pIC50	6.41	nM	IC50	Bioorg Med Chem (2008) 16: 4304-4312 [PMID:18337104]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	8.27	pIC50	5.34	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.	F	8.56	pIC50	2.73	nM	IC50	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1	F	8.56	pIC50	2.73	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonistic activity towards Opioid receptor delta 1 as inhibitory activity towards electrically stimulated mouse vas deferens	F	8.57	pIC50	2.7	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Agonist activity at delta opioid receptor in mouse vas deferens	F	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Displacement of [3H]DPDPE from mouse delta opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membrane	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.	B	8.4	pKi	4	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting method	B	8.45	pKi	3.53	nM	Ki	Bioorg Med Chem (2017) 25: 2406-2422 [PMID:28314512]
ChEMBL	Inhibition of [3H]DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1109-1111 [PMID:10843229]
ChEMBL	Inhibition of binding of [3H]-DPDPE to opioid receptor delta 1 from rat brain membrane.	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1741-1743 [PMID:11425550]
ChEMBL	Affinity of [H]DADLE to the delta opioid receptor from rat brain	B	8.8	pKi	1.57	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand	B	8.8	pKi	1.57	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Inhibitory activity against Opioid receptor delta 1 in rat brain membranes using [3H]DADLE as a radioligand.	B	8.82	pKi	1.5	nM	Ki	J Med Chem (2000) 43: 3193-3196 [PMID:10956228]
ChEMBL	Displacement of [3H]DPDPE from DOR in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting method	B	8.92	pKi	1.2	nM	Ki	J Med Chem (2019) 62: 893-907 [PMID:30543421]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	6.37	pIC50	430	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of [3H]- DADLE binding to Rat brain Opioid receptor delta 1	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]DADAL in rat brain membranes.	B	8.54	pIC50	2.9	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	8.54	pIC50	2.88	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.	B	8.97	pIC50	1.06	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Agonist activity at rat delta opioid receptor expressed in rat C6 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by radioimmunoassay	F	6.78	pEC50	166	nM	EC50	J Med Chem (2009) 52: 7724-7731 [PMID:19788201]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptor	B	5.38	pKi	4169	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Binding affinity towards opioid kappa receptor using [3H]U-69593 as radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid kappa receptor using [3H]U-69593 as radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand.	B	5.61	pIC50	2480	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand	B	5.61	pIC50	2480	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human kappa opioid receptor expressed in HEK293 cells by CellKey method	B	5.28	pEC50	5264	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Displacement of [3H]U-69,593 from mouse brain kappa opioid receptor by scintillation counting analysis	B	5.56	pKi	2750	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligand	B	5.87	pKi	1348	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain	B	5.45	pKi	3535	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Displacement of [3H]U69593 from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	5.44	pIC50	3601	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against kappa opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6 nM nor-BNI	F	6.2	pKd	629	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.	B	4.93	pKi	11700	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranes	B	5.06	pKi	8760	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]U-69593 radioligand	B	5.45	pKi	3535	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum membrane	B	6	pKi	>1000	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Binding affinity for Opioid receptor kappa 1 by the inhibition of binding of [3H]U-69593 in guinea pig brain membranes.	B	5.15	pIC50	7070	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Agonist activity at kappa opioid receptor in myenteric plexus muscle from guinea pig	F	5.9	pIC50	1258.93	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Inhibition of [3H]- U69,593 binding to Guinea pig Opioid receptor kappa 1	B	6	pIC50	>1000	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Binding affinity for mu opioid receptor	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2109-2112 [PMID:15080989]
ChEMBL	Displacement of [125I]FK33824 from human cloned mu opioid receptor	B	6.45	pKi	352	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5994-5998 [PMID:19800791]
ChEMBL	Binding affinity for micro receptors by the inhibition of binding of [3H]DAMGO to Opioid receptor mu 1 in human cloned receptors.	B	5.32	pIC50	4785	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]FK33824 as radioligand.	B	6.49	pIC50	320	nM	IC50	J Med Chem (2000) 43: 3895-3905 [PMID:11052794]
ChEMBL	Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligand	B	6.49	pIC50	320	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human mu opioid receptor expressed in HEK293 cells by CellKey method	B	9.85	pEC50	0.14	nM	EC50	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]DAMGO from mouse brain mu opioid receptor by scintillation counting analysis	B	5.62	pKi	2383	nM	Ki	Eur J Med Chem (2013) 69: 413-426 [PMID:24090913]
ChEMBL	Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligand	B	5.89	pKi	1300	nM	Ki	J Med Chem (1997) 40: 3192-3198 [PMID:9379438]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain cerebellum membrane	B	6.16	pKi	695	nM	Ki	ACS Med Chem Lett (2014) 5: 368-372 [PMID:24900842]
ChEMBL	Displacement of [3H]DAMGO from mouse mu opioid receptor expressed in HEK293 cells by liquid scintillation counting	B	5.22	pIC50	6066	nM	IC50	Bioorg Med Chem (2009) 17: 6442-6450 [PMID:19646882]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membrane	B	5.09	pKi	8070	nM	Ki	J Med Chem (2004) 47: 1400-1412 [PMID:14998329]
ChEMBL	In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membranes.	B	5.4	pKi	3970	nM	Ki	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
ChEMBL	Affinity of [3H]DAMGO to the mu opioid receptor from rat brain	B	5.79	pKi	1614	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1281-1284 [PMID:10866400]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	5.79	pKi	1614	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity by inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from rat brain membranes	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2000) 10: 1109-1111 [PMID:10843229]
ChEMBL	Inhibition of binding of [3H]DAMGO to opioid receptor mu 1 from rat brain membrane.	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1741-1743 [PMID:11425550]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	5.03	pIC50	9366	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes	B	5.03	pIC50	9366	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes	B	5.24	pIC50	5712	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes	B	5.32	pIC50	4800	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1329-1334 [PMID:10340623]
ChEMBL	Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes	B	5.32	pIC50	4800	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1323-1328 [PMID:10340622]
ChEMBL	Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand.	B	5.6	pIC50	2500	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
ChEMBL	Binding affinity for Opioid receptor mu 1 by the inhibition of binding of [3H]DAMGO in rat brain membranes.	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1997) 40: 2936-2947 [PMID:9288176]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1	B	5.61	pIC50	2467	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6000 nM CTAP	F	6.17	pKd	673	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes blocked with 6000 nM CTAP	F	6.17	pKd	673	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes in unblocked condition	F	6.5	pKd	317	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity against Mu opioid receptor using [35S]GTP-gamma-S, binding assay in guinea pig caudate membranes in unblocked condition	F	6.5	pKd	317	nM	Kd	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Agonist activity at mu opioid receptor in myenteric plexus muscle from guinea pig	F	5	pIC50	<10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Agonistic activity for Opioid receptor mu 1 as inhibitory activity towards electrically stimulated guinea pig ileum	F	5.26	pIC50	5457	nM	IC50	J Med Chem (1996) 39: 2081-2086 [PMID:8642567]
ChEMBL	Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor mu 1	F	5.26	pIC50	5457	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.	F	5.26	pIC50	5450	nM	IC50	J Med Chem (1999) 42: 5455-5463 [PMID:10639287]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5.2	pIC50	6309.57	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5.4	pIC50	3981.07	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.5	pIC50	3162.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5.5	pIC50	3162.28	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5.6	pIC50	2511.89	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5.6	pIC50	2511.89	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]