Ligand id: 7541

Name: ixekizumab

Compound class Antibody
Approved drug? Yes (FDA & EMA (2016))
International Nonproprietary Names
INN number INN
9467 ixekizumab
LY-2439821 | LY2439821 | Taltz®
Ixekizumab binds to IL-17A and blocks its action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. A protein BLAST search using the variable region of the heavy chain of ixekizumab identifies this as sequence 118 from patent US7838638 [1]. In this patent binding affinity data for human IL-17 is provided for several antibody clones, but it does not specify which was chosen as ixekizumab, although mAbs 126, 121 and 104 did undergo additional experimental investigations.
Database Links
Specialist databases
IMGT/mAb-DB 380
Other databases
GtoPdb PubChem SID 187051842
PubChem SID 187051842
Search PubMed clinical trials ixekizumab
Search PubMed titles ixekizumab
Search PubMed titles/abstracts ixekizumab
Wikipedia Ixekizumab