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ChEMBL ligand: CHEMBL283807 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Histidine triad nucleotide-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5878] [UniProtKB: P49773] | ||||||||
ChEMBL | Binding affinity to full-length human N-terminal His6-tagged Hint1 expressed in Escherichia coli Rosetta 2 pLysS cells by isothermal titration calorimetry | B | 4.17 | pKd | 67000 | nM | Kd | US-20180065965-A1. SULFAMIDE AND SULFAMATE INHIBITORS OF hHint1 (2018) |
Hypoxanthine-guanine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2360] [UniProtKB: P00492] | ||||||||
ChEMBL | Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay | B | 5.24 | pKi | 5800 | nM | Ki | J Med Chem (2009) 52: 4391-4399 [PMID:19527031] |
ChEMBL | Inhibition of human HGPRT | B | 5.24 | pKi | 5800 | nM | Ki | J Med Chem (2015) 58: 4822-4838 [PMID:25915781] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]