5'-GMP [Ligand Id: 5123] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL283807
  • Histidine triad nucleotide-binding protein 1 in Human [ChEMBL: CHEMBL5878] [UniProtKB: P49773]
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  • Hypoxanthine-guanine phosphoribosyltransferase in Human [ChEMBL: CHEMBL2360] [UniProtKB: P00492]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Histidine triad nucleotide-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5878] [UniProtKB: P49773]
ChEMBL Binding affinity to full-length human N-terminal His6-tagged Hint1 expressed in Escherichia coli Rosetta 2 pLysS cells by isothermal titration calorimetry B 4.17 pKd 67000 nM Kd US-20180065965-A1. SULFAMIDE AND SULFAMATE INHIBITORS OF hHint1 (null)
Hypoxanthine-guanine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2360] [UniProtKB: P00492]
ChEMBL Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay B 5.24 pKi 5800 nM Ki J. Med. Chem. (2009) 52: 4391-4399 [PMID:19527031]
ChEMBL Inhibition of human HGPRT B 5.24 pKi 5800 nM Ki J. Med. Chem. (2015) 58: 4822-4838 [PMID:25915781]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]