AC-42 [Ligand Id: 289] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1242950 (AC-42)
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • This target only has 1 pki data point
  • 6
1 CHEMBL1242950_lig_chart_1 Acetylcholinesterase Human
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  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • 6
2 CHEMBL1242950_lig_chart_2 Adenosine A1 receptor Human
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
  • This target only has 1 pki data point
  • 6
3 CHEMBL1242950_lig_chart_3 Adenosine A2a receptor Human
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
  • This target only has 1 pki data point
  • 6
4 CHEMBL1242950_lig_chart_4 Adenosine A3 receptor Human
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  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • This target only has 1 pki data point
  • 7.74
5 CHEMBL1242950_lig_chart_5 Alpha-1a adrenergic receptor Human
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
  • This target only has 1 pki data point
  • 7.19
6 CHEMBL1242950_lig_chart_6 Alpha-1b adrenergic receptor Human
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • This target only has 1 pki data point
  • 7.4
7 CHEMBL1242950_lig_chart_7 Alpha-1d adrenergic receptor Human
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 6.28
8 CHEMBL1242950_lig_chart_8 Alpha-2a adrenergic receptor Human
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 6.08
9 CHEMBL1242950_lig_chart_9 Alpha-2b adrenergic receptor Human
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
  • 6
10 CHEMBL1242950_lig_chart_10 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 1 pki data point
  • 6
11 CHEMBL1242950_lig_chart_11 Beta-2 adrenergic receptor Human
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • This target only has 1 pki data point
  • 6
12 CHEMBL1242950_lig_chart_12 Cannabinoid CB1 receptor Human
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
  • This target only has 1 pki data point
  • 6
13 CHEMBL1242950_lig_chart_13 Cholecystokinin B receptor Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • This target only has 1 pki data point
  • 6
14 CHEMBL1242950_lig_chart_14 Dopamine D1 receptor Human
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • 6.56
15 CHEMBL1242950_lig_chart_15 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 6
16 CHEMBL1242950_lig_chart_16 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
  • 7.96
17 CHEMBL1242950_lig_chart_17 Dopamine D4 receptor Human
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  • DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
  • This target only has 1 pki data point
  • 6
18 CHEMBL1242950_lig_chart_18 Dopamine transporter Human
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  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
  • This target only has 1 pki data point
  • 6
19 CHEMBL1242950_lig_chart_19 Endothelin receptor ET-A Human
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  • Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
  • This target only has 1 pki data point
  • 6
20 CHEMBL1242950_lig_chart_20 Glucocorticoid receptor Human
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  • CHT/High-affinity choline transporter in Human [ChEMBL: CHEMBL4507] [GtoPdb: 914] [UniProtKB: Q9GZV3]
  • This target only has 1 pki data point
  • 6
21 CHEMBL1242950_lig_chart_21 High-affinity choline transporter Human
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
  • This target only has 1 pki data point
  • 6.21
22 CHEMBL1242950_lig_chart_22 Histamine H1 receptor Human
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • This target only has 1 pki data point
  • 6
23 CHEMBL1242950_lig_chart_23 Histamine H2 receptor Human
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  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
  • This target only has 1 pki data point
  • 6
24 CHEMBL1242950_lig_chart_24 Histamine H3 receptor Human
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
  • This target only has 1 pki data point
  • 6
25 CHEMBL1242950_lig_chart_25 Kappa opioid receptor Human
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
  • This target only has 1 pki data point
  • 6
26 CHEMBL1242950_lig_chart_26 MAP kinase p38 alpha Human
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  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
  • This target only has 1 pki data point
  • 6
27 CHEMBL1242950_lig_chart_27 Melanocortin receptor 4 Human
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  • MT1 receptor/Melatonin receptor 1A in Human [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039]
  • This target only has 1 pki data point
  • 6
28 CHEMBL1242950_lig_chart_28 Melatonin receptor 1A Human
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  • Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
  • This target only has 1 pki data point
  • 6
29 CHEMBL1242950_lig_chart_29 Monoamine oxidase A Human
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
  • This target only has 1 pki data point
  • 6
30 CHEMBL1242950_lig_chart_30 Mu opioid receptor Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • 6.2
31 CHEMBL1242950_lig_chart_31 Muscarinic acetylcholine receptor M1 Human
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • 6
32 CHEMBL1242950_lig_chart_32 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • 5.78
33 CHEMBL1242950_lig_chart_33 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • 5.93
34 CHEMBL1242950_lig_chart_34 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • 5.67
35 CHEMBL1242950_lig_chart_35 Muscarinic acetylcholine receptor M5 Human
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  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
  • This target only has 1 pki data point
  • 6
36 CHEMBL1242950_lig_chart_36 Neurokinin 1 receptor Human
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
  • This target only has 1 pki data point
  • 6
37 CHEMBL1242950_lig_chart_37 Neurokinin 2 receptor Human
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  • nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472465] [UniProtKB: P17787P43681]
  • This target only has 1 pki data point
  • 6
38 CHEMBL1242950_lig_chart_38 Neuronal acetylcholine receptor; alpha4/beta2 Human
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  • Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
  • This target only has 1 pki data point
  • 6
39 CHEMBL1242950_lig_chart_39 Neuropeptide Y receptor type 1 Human
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  • NTS1 receptor/Neurotensin receptor 1 in Human [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
  • This target only has 1 pki data point
  • 6
40 CHEMBL1242950_lig_chart_40 Neurotensin receptor 1 Human
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  • Nischarin in Human [ChEMBL: CHEMBL3923] [UniProtKB: Q9Y2I1]
  • This target only has 1 pki data point
  • 6
41 CHEMBL1242950_lig_chart_41 Nischarin Human
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
  • 6
42 CHEMBL1242950_lig_chart_42 Norepinephrine transporter Human
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  • Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
  • This target only has 1 pki data point
  • 6
43 CHEMBL1242950_lig_chart_43 Quinone reductase 2 Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • This target only has 1 pki data point
  • 6.55
44 CHEMBL1242950_lig_chart_44 Serotonin 1a (5-HT1a) receptor Human
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
  • This target only has 1 pki data point
  • 6
45 CHEMBL1242950_lig_chart_45 Serotonin 1b (5-HT1b) receptor Human
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
  • 6
46 CHEMBL1242950_lig_chart_46 Serotonin 2a (5-HT2a) receptor Human
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
  • 6
47 CHEMBL1242950_lig_chart_47 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
  • 6
48 CHEMBL1242950_lig_chart_48 Serotonin 2c (5-HT2c) receptor Human
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
  • This target only has 1 pki data point
  • 6
49 CHEMBL1242950_lig_chart_49 Serotonin 3a (5-HT3a) receptor Human
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • This target only has 1 pki data point
  • 6
50 CHEMBL1242950_lig_chart_50 Serotonin 4 (5-HT4) receptor Human
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • This target only has 1 pki data point
  • 6
51 CHEMBL1242950_lig_chart_51 Serotonin 7 (5-HT7) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 6
52 CHEMBL1242950_lig_chart_52 Serotonin transporter Human
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
  • This target only has 1 pki data point
  • 6
53 CHEMBL1242950_lig_chart_53 Tyrosine-protein kinase Lyn Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Binding affinity to human acetylcholine esterase by radioligand displacement assay B 6 pKi >=1000 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Binding affinity to human adenosine A1 receptor by radioligand displacement assay B 6 pKi >=1000 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
ChEMBL Binding affinity to human adenosine A1 receptor agonist site by radioligand displacement assay B 6 pKi >=1000 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity to human adenosine A2A receptor by radioligand displacement assay B 6 pKi >=1000 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity to human adenosine A3 receptor by radioligand displacement assay B 6 pKi >=1000 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity to human adrenergic alpha1A receptor by radioligand displacement assay B 7.74 pKi 18 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Binding affinity to human adrenergic Alpha-1B receptor by radioligand displacement assay B 7.19 pKi 65 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay B 7.4 pKi 40 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity to human adrenergic alpha2A receptor by radioligand displacement assay B 6.28 pKi 530 nM Ki J. Med. Chem. (2010) 53: 6386-6397 [PMID:20684563]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Binding affinity to adrenergic alpha2B receptor by radioligand displacement assay B 6.08 pKi 840 nM Ki