ChEMBL ligand: CHEMBL13045 (Chelerythrine)
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191] There should be some charts here, you may need to enable JavaScript!
SERCA1/Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 in Human [ChEMBL: CHEMBL3136] [GtoPdb: 840] [UniProtKB: O14983] There should be some charts here, you may need to enable JavaScript!
P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572] There should be some charts here, you may need to enable JavaScript!
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Human [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	5.84	pIC50	1450	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL	Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	5.07	pIC50	8580	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Competitive inhibition of recombinant human MAO-A using kynuramine as substrate by Lineweaver-Burk plot analysis	B	6.66	pKi	220	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
ChEMBL	Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric method	B	6.26	pIC50	550	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method	B	4.7	pIC50	>20000	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity to human 6xHis-tagged PPARgamma ligand binding domain (206 to 477 residues) by TR-FRET assay	B	6.25	pIC50	566	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4157-4164 [PMID:27503683]
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
ChEMBL	Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled method	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2020) 63: 1937-1963 [PMID:32030976]
SERCA1/Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3136] [GtoPdb: 840] [UniProtKB: O14983]
ChEMBL	Inhibition of SERCA1a (unknown origin) incubated for 10 mins by enzyme-coupled method	B	4.57	pIC50	27000	nM	IC50	J Med Chem (2020) 63: 1937-1963 [PMID:32030976]
P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572]
GtoPdb	Inhibition of ATP-induced 86Rb+ (K+) efflux in human B-lymphocytes	-	5.25	pIC50	5600	nM	IC50	Br J Pharmacol (2004) 142: 1015-9 [PMID:15210579]
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156]
GtoPdb	-	-	7.62	pIC50	24	nM	IC50	Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb	-	-	6.05	pIC50	900	nM	IC50	Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]