chelerythrine [Ligand Id: 5953] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL13045 (Chelerythrine)
  • Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
  • This target only has 1 pki data point
1 CHEMBL13045_lig_chart_1 Monoamine oxidase A Human
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  • Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
  • This target only has 0 pki data point
2 CHEMBL13045_lig_chart_2 Monoamine oxidase B Human
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  • P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572]
  • This target only has 0 pki data point
3 CHEMBL13045_lig_chart_3 P2X7 Human
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  • protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156]
  • This target only has 0 pki data point
4 CHEMBL13045_lig_chart_4 protein kinase C epsilon Human
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  • protein kinase A in Human [GtoPdb: 1694]
  • This target only has 0 pki data point
5 CHEMBL13045_lig_chart_5 protein kinase A Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Competitive inhibition of recombinant human MAO-A using kynuramine as substrate by Lineweaver-Burk plot analysis B 6.66 pKi 220 nM Ki Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
ChEMBL Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric method B 6.26 pIC50 550 nM IC50 Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572]
GtoPdb Inhibition of ATP-induced 86Rb+ (K+) efflux in human B-lymphocytes - 5.25 pIC50 5600 nM IC50 Br. J. Pharmacol. (2004) 142: 1015-9 [PMID:15210579]
protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156]
GtoPdb - - 7.62 pIC50 24 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb - - 6.05 pIC50 900 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]