ChEMBL ligand: CHEMBL267178 (CGS-27023A)
MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] There should be some charts here, you may need to enable JavaScript!
MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] There should be some charts here, you may need to enable JavaScript!
MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] There should be some charts here, you may need to enable JavaScript!
MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] There should be some charts here, you may need to enable JavaScript!
MMP8/Matrix metalloproteinase 8 in Human [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] There should be some charts here, you may need to enable JavaScript!
MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] There should be some charts here, you may need to enable JavaScript!
MMP25 in Human [GtoPdb: 1647] [UniProtKB: Q9NPA2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
GtoPdb	-	-	7.25	pIC50	56	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
ChEMBL	Inhibition of recombinant human pro-MMP1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay	B	7.25	pIC50	56	nM	IC50	Bioorg Med Chem (2019) 27: 196-207 [PMID:30522899]
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL	Inhibition of recombinant human MT1-MMP catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 min by fluorometric assay	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem (2019) 27: 196-207 [PMID:30522899]
GtoPdb	-	-	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL	Inhibition of recombinant human MMP2 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2413-2417 [PMID:29921475]
GtoPdb	-	-	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
ChEMBL	Inhibition of recombinant human proMMP2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay	B	7.6	pIC50	25	nM	IC50	Bioorg Med Chem (2019) 27: 196-207 [PMID:30522899]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL	Inhibition of recombinant human MMP3 (Tyr18 to Cys477 residues) expressed in mouse myeloma cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2017) 138: 979-992 [PMID:28756264]
ChEMBL	Inhibition of recombinant human MMP3 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2413-2417 [PMID:29921475]
GtoPdb	-	-	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL	Inhibition of recombinant human MMP8 (Phe21 to Gly467 residues) expressed in mouse myeloma cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2017) 138: 979-992 [PMID:28756264]
GtoPdb	-	-	8.11	pIC50	7.7	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL	Inhibition of recombinant human MMP9 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluorescence assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2413-2417 [PMID:29921475]
ChEMBL	Inhibition of recombinant human MMP9 (Ala20 to Asp707 residues) expressed in CHO cells using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2017) 138: 979-992 [PMID:28756264]
ChEMBL	Inhibition of recombinant human proMMP9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay	B	8.32	pIC50	4.8	nM	IC50	Bioorg Med Chem (2019) 27: 196-207 [PMID:30522899]
GtoPdb	-	-	8.32	pIC50	4.8	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]
MMP25 in Human [GtoPdb: 1647] [UniProtKB: Q9NPA2]
GtoPdb	-	-	8.82	pIC50	1.5	nM	IC50	Eur J Med Chem (2011) 46: 2617-29 [PMID:21514700]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]