MMP25 | M10: Matrix metallopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1647

Nomenclature: MMP25

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 562 16p13.3 MMP25 matrix metallopeptidase 25
Mouse - 615 17 A3.3 Mmp25 matrix metallopeptidase 25
Rat - - 10q12 Mmp25 matrix metallopeptidase 25
Previous and Unofficial Names
leukolysin | MT6-MMP | MMP20 | MMPL1
Database Links
Specialist databases
MEROPS M10.024 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CGS-27023A Hs Inhibition 8.8 pIC50 1
pIC50 8.8 (IC50 1.5x10-9 M) [1]


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1. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem, 46 (7): 2617-29. [PMID:21514700]

How to cite this page

M10: Matrix metallopeptidase: MMP25. Last modified on 16/03/2017. Accessed on 19/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,