Synonyms: CC-99282 | CC99282 | compound 1 [US20220324855]
Compound class:
Synthetic organic
Comment: Golcadomide (CC-99282) is an oral molecular glue that promotes degradation of IKZF1/3 transcription factors (Ikaros/Aiolos) by engaging the cereblon E3 ubiquitin ligase complex. Structurally golcadomide is a novel thalidomide analogue (known as a CELMoD/cereblon E3 ligase modulator). It has immunomodulatory actions, with enhanced antiproliferative and proapoptotic activities compared to lenalidomide. The chemical structure for golcadomide is claimed in several Celgene patents (e.g. US20220324855A1 [1]).
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione |
International Nonproprietary Names ![]() |
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INN number | INN |
12305 | golcadomide |
Synonyms ![]() |
CC-99282 | CC99282 | compound 1 [US20220324855] |
Database Links ![]() |
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ChEMBL Ligand | CHEMBL5095226 |
GtoPdb PubChem SID | 485206142 |
PubChem CID | 146195299 |
Search Google for chemical match using the InChIKey | NZYDBVQXOGPDDU-QHCPKHFHSA-N |
Search Google for chemicals with the same backbone | NZYDBVQXOGPDDU |
Search PubMed clinical trials | golcadomide |
Search PubMed titles | golcadomide |
Search PubMed titles/abstracts | golcadomide |
UniChem Compound Search for chemical match using the InChIKey | NZYDBVQXOGPDDU-QHCPKHFHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NZYDBVQXOGPDDU-QHCPKHFHSA-N |
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Golcadomide (links to external site)
Cat. No. HY-146237 |