Synonyms: CC-99282 | CC99282 | compound 1 [US20220324855]
Compound class:
Synthetic organic
Comment: Golcadomide (CC-99282) is an oral molecular glue that promotes degradation of IKZF1/3 transcription factors (Ikaros/Aiolos) by engaging the cereblon E3 ubiquitin ligase complex. Structurally golcadomide is a novel thalidomide analogue (known as a CELMoD/cereblon E3 ligase modulator). It has immunomodulatory actions, with enhanced antiproliferative and proapoptotic activities compared to lenalidomide. The chemical structure for golcadomide is claimed in several Celgene patents (e.g. US20220324855A1 [1]).
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Bioactivity Comments |
Golcadomide (CC-99282) inhibits the growth of a range of lymphoma cells in vitro and antitumor activity in lymphoma xenograft models [1]. |
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