PF-06751979

Ligand id: 9943

Name: PF-06751979

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 168.34
Molecular weight 559.12
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[2-[(4aR,6S,8aR)-2-benzamido-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(difluoromethoxy)pyridine-2-carboxamide
Synonyms
compound 64 [PMID: 29613789] | PF06751979
Comments
This recent (April 2018) Pfizer BACE1 inhibitor for Alzheimer's disease showed brain penetration, potent in vivo efficacy and broad selectivity over related aspartyl proteases including BACE2 [1].
Database Links
GtoPdb PubChem SID 374883831
PubChem CID 118435422
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