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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|Compound 86 is reported as a selective inhibitor of sirtuin 2 (SIRT2) , a NAD-dependent protein deacetylase with protective effects neurodegenerative disease. Compound 86 is shown to be competitive with NAD+ and the enzyme's peptide substrate, with acceptable blood-brain barrier penetrance (a property essential for any drug being developed for neuroprotective activity).
Drug-like SIRT2 inhibitors are being developed to determine if SIRT2 blockade could be of clinical benefit in Parkinson's disease .
|GtoPdb PubChem SID||315661326|
|Search Google for chemical match using the InChIKey||VKLKXFOZNHEBSW-UHFFFAOYSA-N|
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|Search UniChem for chemical match using the InChIKey||VKLKXFOZNHEBSW-UHFFFAOYSA-N|
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