5Z-7-oxozeaenol [Ligand Id: 8077] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1077979 ((5Z)-7-Oxozeaenol, 5Z-7-Oxozeaenol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1] | ||||||||
| ChEMBL | Binding affinity to BIKE (unknown origin) assessed as dissociation constant | B | 8.42 | pKd | 3.8 | nM | Kd | J Med Chem (2022) 65: 935-954 [PMID:33970631] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Inhibition of MAP2K1 (unknown origin) using unphosphorylated GST-tagged ERK2 substrate protein assessed as phosphorylation by ELISA | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 593-596 [PMID:25529738] |
| ChEMBL | Inhibition of MEK1 | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2012) 55: 6243-6262 [PMID:22621397] |
| ChEMBL | Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem (2017) 25: 838-846 [PMID:28011204] |
| mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| ChEMBL | Inhibition of MKK4 | B | 5.52 | pIC50 | >3000 | nM | IC50 | J Med Chem (2012) 55: 6243-6262 [PMID:22621397] |
| mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
| ChEMBL | Inhibition of MAP2K7 (unknown origin) using unphosphorylated GST-tagged JNK1 substrate protein assessed as phosphorylation by ELISA | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 593-596 [PMID:25529738] |
| ChEMBL | Inhibition of MEK7 | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2012) 55: 6243-6262 [PMID:22621397] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of ERK2 (unknown origin) using FITC-labeled substrate peptide assessed as phosphorylation | B | 5.17 | pIC50 | 6800 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 593-596 [PMID:25529738] |
| ChEMBL | Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assay | B | 6.13 | pIC50 | 738 | nM | IC50 | Bioorg Med Chem (2017) 25: 838-846 [PMID:28011204] |
| ChEMBL | Inhibition of Erk2 | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2012) 55: 6243-6262 [PMID:22621397] |
| mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
| ChEMBL | Inhibition of TAK1 (unknown origin) using unphosphorylated GST-tagged MAP2K7 substrate protein assessed as phosphorylation by ELISA | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 593-596 [PMID:25529738] |
| ChEMBL | Inhibition of TAK1 (unknown origin) | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2015) 23: 6993-6999 [PMID:26481152] |
| ChEMBL | Inhibition of full length TAK1 (unknown origin) fused with TAB1 using biotin-MKK6 as substrate by AlphaScreen assay | B | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2016) 24: 4206-4217 [PMID:27448772] |
| GtoPdb | Assayed using TAK1/TAB1 (TAK1-binding protein 1) fusion protein for full enzymatic activity. Inhibition of kinase activity. | - | 8.05 | pIC50 | 9 | nM | IC50 |
ACS Chem Biol (2013) 8: 643-50 [PMID:23272696]; J Med Chem (2012) 55: 6243-62 [PMID:22621397] |
| ChEMBL | Inhibition of TAK1 (unknown origin) expressed in sf9 cells assessed as 32P level incorporation into myelin basic protein incubated for 5 mins at 30 degC by immunoprecipitation method | B | 8.09 | pIC50 | 8.1 | nM | IC50 | Bioorg Med Chem (2015) 23: 6993-6999 [PMID:26481152] |
| ChEMBL | Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay | B | 8.25 | pIC50 | 5.6 | nM | IC50 | Bioorg Med Chem (2017) 25: 838-846 [PMID:28011204] |
| ChEMBL | Inhibition of TAK1 (unknown origin) by LanthaScreen assay | B | 8.25 | pIC50 | 5.6 | nM | IC50 | Bioorg Med Chem (2017) 25: 1320-1328 [PMID:28038940] |
| RELA proto-oncogene, NF-kB subunit/Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [GtoPdb: 3280] [UniProtKB: Q04206] | ||||||||
| ChEMBL | Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA | B | 6.6 | pIC50 | 250 | nM | IC50 | J Nat Prod (2011) 74: 1126-1131 [PMID:21513293] |
| Phospholipase A-2-activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6114] [UniProtKB: Q9Y263] | ||||||||
| ChEMBL | Inhibition of TNFalpha-PLAP (unknown origin) | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2017) 60: 839-885 [PMID:27996267] |
| mitogen-activated protein kinase kinase kinase 7/TAK1/TAB1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038499] [GtoPdb: 2082] [UniProtKB: O43318, Q15750] | ||||||||
| ChEMBL | Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assay | B | 8.05 | pIC50 | 9 | nM | IC50 | Eur J Med Chem (2019) 163: 660-670 [PMID:30576901] |
| GtoPdb | Assayed using TAK1/TAB1 (TAK1-binding protein 1) fusion protein for full enzymatic activity. Inhibition of kinase activity. | - | 8.05 | pIC50 | 9 | nM | IC50 |
ACS Chem Biol (2013) 8: 643-50 [PMID:23272696]; J Med Chem (2012) 55: 6243-62 [PMID:22621397] |
| ChEMBL | Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1724-1727 [PMID:21316225] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
