benserazide [Ligand Id: 5150] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1096979 (Benserazide, Benserazide (as hydrochloride), Benserazide hcl, Benserazide hydrochloride, NSC-755907, RO 4-4602, RO-4-4602, Serazide)
  • Genome polyprotein in Coxsackievirus B3 (strain Nancy) [ChEMBL: CHEMBL2396505] [UniProtKB: P03313]
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  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125313932063261] [UniProtKB: P0DTD1]
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  • Cystathionine β-synthase in Human [GtoPdb: 1443] [UniProtKB: P35520]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Genome polyprotein in Coxsackievirus B3 (strain Nancy) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396505] [UniProtKB: P03313]
ChEMBL Inhibition of recombinant Coxsackievirus B3 3C protease expressed in Escherichia coli BL21 (DE3) preincubated for 5 mins followed by addition of NMA-EALFQGPPVK-DNP-rrr-NH2 as substrate measured every 10 mins for 2 hrs by FRET-based enzyme assay B 5.62 pIC50 2400 nM IC50 Eur J Med Chem (2016) 120: 202-216 [PMID:27191615]
Hexokinase type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2640] [UniProtKB: P52789]
ChEMBL Inhibition of HK2 (unknown origin) using glucose-6-phosphate dehydrogenase as substrate preincubated for 10 mins followed by substrate addition B 5.26 pIC50 5520 nM IC50 J Nat Prod (2019) 82: 1114-1119 [PMID:31013087]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125313932063261] [UniProtKB: P0DTD1]
ChEMBL SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate F 6.85 pIC50 140 nM IC50 Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
Cystathionine β-synthase in Human [GtoPdb: 1443] [UniProtKB: P35520]
GtoPdb - - 4.52 pIC50 ~30000 nM IC50 Pharmacol Res (2016) 113: 18-37 [PMID:27521834]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]