ChEMBL ligand: CHEMBL1639 (Aliskiren, Rasilez, SPP-100, SPP100)
Cathepsin D in Bovine [ChEMBL: CHEMBL4106] [UniProtKB: P80209] There should be some charts here, you may need to enable JavaScript!
Protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12] There should be some charts here, you may need to enable JavaScript!
Renin in Rhesus macaque [ChEMBL: CHEMBL1287631] [UniProtKB: Q6DLW5] renin/Renin in Human [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] Renin in Rabbit [ChEMBL: CHEMBL1287632] [UniProtKB: Q7M3D2] renin/Renin in Mouse [ChEMBL: CHEMBL2615] [GtoPdb: 2413] [UniProtKB: P06281] renin/Renin in Rat [ChEMBL: CHEMBL2322] [GtoPdb: 2413] [UniProtKB: P08424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cathepsin D in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4106] [UniProtKB: P80209]
ChEMBL	Inhibition of bovine cathepsin D	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4863-4867 [PMID:19615901]
Protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366517] [UniProtKB: Q9YQ12]
ChEMBL	Inhibition of HIV1 recombinant protease using Lys-Ala-Arg-Val-Nle-Nph-Glu-Ala-Nle-NH2 as substrate by spectrophotometric analysis	B	7.12	pKi	76.5	nM	Ki	J Med Chem (2012) 55: 5784-5796 [PMID:22621689]
Renin in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287631] [UniProtKB: Q6DLW5]
ChEMBL	Inhibition of renin in monkey plasma	B	8.92	pIC50	1.2	nM	IC50	Bioorg Med Chem (2018) 26: 3261-3286 [PMID:29754833]
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797]
ChEMBL	Inhibition of recombinant human renin using 5-FAM/QXL 520 as substrate pretreated for 30 mins followed by substrate addition measured at 1 min interval for 15 mins by FRET assay	B	8.52	pIC50	3	nM	IC50	Bioorg Med Chem (2017) 25: 3947-3963 [PMID:28601508]
ChEMBL	Inhibition of renin activity in human plasma by competitive radio immunoassay	B	8.6	pIC50	2.5	nM	IC50	ACS Med Chem Lett (2022) 13: 1351-1357 [PMID:35978678]
ChEMBL	Inhibition of human plasma renin	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (2022) 65: 10882-10897 [PMID:35939295]
ChEMBL	Inhibition of human recombinant renin preincubated for 30 mins followed by substrate addition measured after 15 mins by fluorescence analysis	B	8.64	pIC50	2.3	nM	IC50	Eur J Med Chem (2015) 103: 269-288 [PMID:26363506]
ChEMBL	Inhibition of renin measured every 30 secs for 15 mins by fluorimetric analysis	B	8.66	pIC50	2.21	nM	IC50	Bioorg Med Chem (2011) 19: 4238-4249 [PMID:21708467]
ChEMBL	Inhibition of renin in human plasma by radioimmunoassay	B	9.08	pIC50	0.84	nM	IC50	Bioorg Med Chem (2018) 26: 3261-3286 [PMID:29754833]
ChEMBL	Inhibition of recombinant glycosylated human renin expressed in CHO cells	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2022) 65: 10882-10897 [PMID:35939295]
ChEMBL	Inhibition of human recombinant renin using Nma-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-Dnp substrate incubated for 1 hr by FRET	B	9.15	pIC50	0.7	nM	IC50	ACS Med Chem Lett (2022) 13: 1351-1357 [PMID:35978678]
ChEMBL	Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasma	B	9.19	pIC50	0.65	nM	IC50	Bioorg Med Chem Lett (2010) 20: 694-699 [PMID:19959358]
ChEMBL	Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassay	B	9.19	pIC50	0.65	nM	IC50	ACS Med Chem Lett (2011) 2: 747-751 [PMID:24900262]
GtoPdb	-	-	9.2	pIC50	0.6	nM	IC50	Clin Exp Pharmacol Physiol (2008) 35: 426-30 [PMID:18307734]
ChEMBL	Inhibition of human recombinant renin in presence of human plasma by competitive radioimmunoassay	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3541-3545 [PMID:19457666]
ChEMBL	Inhibition of human recombinant rennin in buffer assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassay	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2009) 52: 3689-3702 [PMID:19358611]
ChEMBL	Inhibition of purified recombinant human renin	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4863-4867 [PMID:19615901]
ChEMBL	Inhibition of human plasma renin	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4863-4867 [PMID:19615901]
ChEMBL	Inhibition of renin in plasma	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2010) 53: 7490-7520 [PMID:20731374]
ChEMBL	Inhibition of human renin	B	9.22	pIC50	0.6	nM	IC50	Eur J Med Chem (2011) 46: 2469-2476 [PMID:21497958]
ChEMBL	Inhibition of human renin	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2012) 55: 5784-5796 [PMID:22621689]
ChEMBL	Inhibition of renin (unknown origin)	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1592-1596 [PMID:25728416]
ChEMBL	Inhibition of recombinant human renin	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem (2017) 25: 3947-3963 [PMID:28601508]
ChEMBL	Inhibition of human recombinant renin	B	9.22	pIC50	0.6	nM	IC50	ACS Med Chem Lett (2022) 13: 1351-1357 [PMID:35978678]
ChEMBL	Inhibition of renin activity in human plasma	B	9.22	pIC50	0.6	nM	IC50	ACS Med Chem Lett (2022) 13: 1351-1357 [PMID:35978678]
ChEMBL	Inhibition of trypsin-activated human recombinant renin	B	9.28	pIC50	0.53	nM	IC50	Bioorg Med Chem Lett (2010) 20: 694-699 [PMID:19959358]
ChEMBL	Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiotensin1 product after 2 hrs by competive radioimmunoassay	B	9.28	pIC50	0.53	nM	IC50	ACS Med Chem Lett (2011) 2: 747-751 [PMID:24900262]
ChEMBL	Inhibition of human recombinant renin	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3541-3545 [PMID:19457666]
ChEMBL	Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetry	B	9.4	pIC50	0.4	nM	IC50	ACS Med Chem Lett (2011) 2: 747-751 [PMID:24900262]
Renin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287632] [UniProtKB: Q7M3D2]
ChEMBL	Inhibition of rabbit renin	B	7.96	pIC50	11	nM	IC50	J Med Chem (2010) 53: 7490-7520 [PMID:20731374]
renin/Renin in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2615] [GtoPdb: 2413] [UniProtKB: P06281]
ChEMBL	Inhibition of mouse renin	B	8.35	pIC50	4.5	nM	IC50	J Med Chem (2010) 53: 7490-7520 [PMID:20731374]
renin/Renin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2322] [GtoPdb: 2413] [UniProtKB: P08424]
ChEMBL	Inhibition of renin in rat plasma	B	7.06	pIC50	88	nM	IC50	Bioorg Med Chem (2018) 26: 3261-3286 [PMID:29754833]
ChEMBL	Inhibition of rat renin	B	7.1	pIC50	80	nM	IC50	J Med Chem (2010) 53: 7490-7520 [PMID:20731374]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]