odanacatib [Ligand Id: 6478] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL481611 (MK0822, Odanacatib, MK-0822)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • cathepsin C/Dipeptidyl peptidase I in Human [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858]
ChEMBL Inhibition of cathepsin B in human HepG2 cells B 5.98 pIC50 1050 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
ChEMBL Inhibition of cathepsin B B 5.99 pIC50 1034 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin F/Cathepsin F in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2517] [GtoPdb: 2347] [UniProtKB: Q9UBX1]
ChEMBL Inhibition of cathepsin F B 6.1 pIC50 795 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin H/Cathepsin H in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2225] [GtoPdb: 2349] [UniProtKB: P09668]
ChEMBL Inhibition of cathepsin H B 8 pIC50 >10 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235]
ChEMBL Inhibition of human cathepsin K B 9.74 pKi 0.18 nM Ki Eur J Med Chem (2018) 144: 201-210 [PMID:29272750]
ChEMBL Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assay B 9 pIC50 <1 nM IC50 J. Med. Chem. (2012) 55: 6363-6374 [PMID:22742641]
ChEMBL Inhibition of cathepsin-k B 9 pIC50 <1 nM IC50 J. Med. Chem. (2012) 55: 8827-8837 [PMID:22984809]
ChEMBL Inhibition of humanized rabbit cathepsin K B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 675-679 [PMID:19117756]
ChEMBL Inhibition of humanized rabbit cathepsin K B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 887-892 [PMID:20061146]
ChEMBL Inhibition of humanized rabbit cathepsin K B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
ChEMBL Inhibition of humanized rabbit cathepsin K B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 920-923 [PMID:21232956]
ChEMBL Inhibition of cathepsin K B 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL Inhibition of human cathepsin K B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527]
Cathepsin K in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3349] [UniProtKB: P43236]
ChEMBL Inhibition of rabbit cathepsin K B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711]
ChEMBL Inhibition of Cathepsin L (unknown origin) using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis B 5.9 pKi 1258.93 nM Ki Bioorg Med Chem (2019) 27: 115083-115083 [PMID:31561938]
ChEMBL Inhibition of cathepsin L in human HepG2 cells B 5.31 pIC50 4843 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
ChEMBL Inhibition of cathepsin L B 5.52 pIC50 2995 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911]
ChEMBL Inhibition of cathepsin V B 6.12 pIC50 762 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774]
ChEMBL Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assay B 6.74 pIC50 183 nM IC50 J. Med. Chem. (2012) 55: 6363-6374 [PMID:22742641]
GtoPdb - - 7.22 pIC50 60 nM IC50 Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527]
ChEMBL Inhibition of cathepsin S B 7.22 pIC50 60 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
ChEMBL Inhibition of cathepsin S in human ramos cells B 7.35 pIC50 45 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2]
GtoPdb - - 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2008) 18: 923-8 [PMID:18226527]
ChEMBL Inhibition of cathepsin Z B 8 pIC50 >10 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis B 6.9 pKi 125.89 nM Ki Bioorg Med Chem (2019) 27: 115083-115083 [PMID:31561938]
cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634]
ChEMBL Inhibition of cathepsin C B 8 pIC50 >10 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 923-928 [PMID:18226527]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]