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ChEMBL ligand: CHEMBL2172394 ((-)-Oleocanthal) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
ChEMBL | Inhibition of c-MET phosphorylation (unknown origin) after 1 hr by Z'-LYTE kinase assay | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem (2013) 21: 2117-2127 [PMID:23403296] |
ChEMBL | Inhibition of recombinant human His-tagged c-MET expressed in baculovirus expression system assessed as reduction in c-MET phosphorylation using Tyr6 as substrate incubated for 1 hr by Z'-lyte assay | B | 5.32 | pIC50 | 4800 | nM | IC50 | Bioorg Med Chem (2016) 24: 113-122 [PMID:26692349] |
TRPA1 in Human [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
GtoPdb | Patch clamp | - | 5.6 | pEC50 | - | - | - | J Neurosci (2011) 31: 999-1009 [PMID:21248124] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]