arketamine [Ligand Id: 9153] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL467505 ((R)-Ketamine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane | B | 5.25 | pKi | 5680 | nM | Ki | Bioorg Med Chem (2009) 17: 3456-3462 [PMID:19345586] |
| ChEMBL | Displacement of [3H]-MK801 from NMDA receptor in rat brain membranes | B | 5.59 | pKi | 2570 | nM | Ki | J Med Chem (2020) 63: 13514-13525 [PMID:32915563] |
| ChEMBL | Displacement of [3H]-MK801 from NMDA receptor in rat brain homogenate | B | 5.85 | pKi | 1400 | nM | Ki | J Med Chem (2020) 63: 13514-13525 [PMID:32915563] |
| ChEMBL | Displacement of [3H]MK-801 from NMDA receptor in Wistar rat brain membranes by scintillation counting analysis | B | 5.67 | pIC50 | 2120 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4131-4135 [PMID:26296478] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
