romidepsin [Ligand Id: 7006] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL343448 (Chromadax, Depsipeptide, FK-228, FK228, FR-901228, FR901228, Istodax, NSC-630176, Romidepsin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
| ChEMBL | Inhibition of BRD4 (unknown origin) | B | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 4051-4055 [PMID:28765013] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| GtoPdb | - | - | 11.82 | pKi | 0 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC1 after 60 mins by fluorescence assay | B | 5.98 | pIC50 | 1050 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 1 (C151S) | B | 6.55 | pIC50 | 280 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant human HDAC1 | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 375-379 [PMID:26706171] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 1 | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of HDAC1 by fluorimetric assay | B | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| ChEMBL | Inhibition of HDAC1 in presence of DTT | B | 8.4 | pIC50 | 3.97 | nM | IC50 | J Med Chem (2007) 50: 5720-5726 [PMID:17958342] |
| ChEMBL | Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Eur J Med Chem (2013) 60: 295-304 [PMID:23313638] |
| ChEMBL | Inhibition of human HDAC1 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Eur J Med Chem (2014) 76: 301-313 [PMID:24589486] |
| ChEMBL | Inhibition of HDAC1 by fluorimetric assay in presence of DTT | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of human HDAC1 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreitol | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2014) 22: 3850-3855 [PMID:24997578] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| ChEMBL | Inhibition of human recombinant HDAC1 after 1 hr by luminescence assay | B | 9.51 | pIC50 | 0.31 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of recombinant HDAC1 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 9.7 | pIC50 | 0.2 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells. | B | 4.44 | pEC50 | 36000 | nM | EC50 | J Med Chem (2003) 46: 4826-4829 [PMID:14584932] |
| histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC10 after 60 mins by fluorescence assay | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC11 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assay | B | 9.52 | pIC50 | 0.3 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 1/Histone deacetylase 1/Nuclear receptor corepressor 2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885590] [GtoPdb: 2658] [UniProtKB: Q13547, Q9Y618] | ||||||||
| GtoPdb | - | - | 11.82 | pKi | 0 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC1/NCOR2 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 5.17 | pIC50 | 6700 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| GtoPdb | - | - | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC2 | B | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC2 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 10.42 | pKi | 0.04 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC2 after 60 mins by fluorescence assay | B | 5.22 | pIC50 | 6070 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 2 | B | 7.33 | pIC50 | 47 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 9 | pIC50 | 1 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 9 | pIC50 | 1 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 2/Histone deacetylase 2/Nuclear receptor corepressor 2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885591] [GtoPdb: 2616] [UniProtKB: Q92769, Q9Y618] | ||||||||
| GtoPdb | - | - | 10.42 | pKi | 0.04 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC2/NCOR2 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC3 | B | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC3 after 60 mins by fluorescence assay | B | 7.21 | pIC50 | 62 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| histone deacetylase 3/Histone deacetylase 3/NCoR1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038484] [GtoPdb: 2617] [UniProtKB: O15379, O75376] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 9.82 | pKi | 0.15 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 7.6 | pKi | 24.9 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay | B | 6.83 | pIC50 | 146.9 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 1 mM H2O2 (Rvb = 0.018 uM) | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0.4 mM H2O2 (Rvb = 0.018 uM) | B | 7.41 | pIC50 | 39 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0.2 mM H2O2 (Rvb = 0.018 uM) | B | 7.7 | pIC50 | 20 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC3/NCOR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | Inhibition of human HDAC4 | B | 7.69 | pKi | 20.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC4 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 7.69 | pKi | 20.5 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 7.69 | pKi | 20.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC4 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC4 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of human recombinant HDAC4 after 1 hr by luminescence assay | B | 5.06 | pIC50 | 8670 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of HDAC4 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assay | B | 6.19 | pIC50 | 647 | nM | IC50 | ACS Med Chem Lett (2014) 5: 905-910 [PMID:25147612] |
| ChEMBL | Inhibition of HDAC4 by fluorimetric assay | B | 6.29 | pIC50 | 510 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of Histone deacetylase 4 in mammalian cells. | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2003) 46: 4826-4829 [PMID:14584932] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 4 | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of human HDAC5 | B | 6.26 | pKi | 550 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC5 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 6.26 | pKi | 550 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 6.26 | pKi | 550 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC5 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 6.52 | pKi | 300.1 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC6 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 mins | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 8.02 | pKi | 9.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC6 | B | 8.02 | pKi | 9.5 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibitory concentration against human Histone deacetylase 6 | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2003) 46: 5097-5116 [PMID:14613312] |
| ChEMBL | Inhibition of recombinant human HDAC6 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay | B | 5.8 | pIC50 | 1595 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569] |
| ChEMBL | Inhibition of recombinant human HDAC6 after 60 mins by fluorescence assay | B | 5.91 | pIC50 | 1220 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC6 in presence of DTT | B | 6.1 | pIC50 | 787 | nM | IC50 | J Med Chem (2007) 50: 5720-5726 [PMID:17958342] |
| ChEMBL | Inhibition of human recombinant HDAC6 after 1 hr by luminescence assay | B | 6.17 | pIC50 | 670 | nM | IC50 | Medchemcomm (2012) 3: 976-981 [PMID:23997923] |
| ChEMBL | Inhibition of HDAC6 by fluorimetric assay in presence of DTT | B | 6.21 | pIC50 | 620 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6770-6772 [PMID:23021104] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 6.55 | pIC50 | 281 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| ChEMBL | Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis | B | 6.7 | pIC50 | 200 | nM | IC50 | ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500] |
| ChEMBL | Inhibition of recombinant human HDAC6 | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 375-379 [PMID:26706171] |
| histone deacetylase 6/Histone deacetylase 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2878] [GtoPdb: 2618] [UniProtKB: Q9Z2V5] | ||||||||
| ChEMBL | Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 6.41 | pIC50 | 390 | nM | IC50 | Eur J Med Chem (2013) 60: 295-304 [PMID:23313638] |
| ChEMBL | Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assay | B | 6.41 | pIC50 | 390 | nM | IC50 | Eur J Med Chem (2014) 76: 301-313 [PMID:24589486] |
| ChEMBL | Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreitol | B | 9.2 | pIC50 | 0.63 | nM | IC50 | Bioorg Med Chem (2014) 22: 3850-3855 [PMID:24997578] |
| histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] | ||||||||
| GtoPdb | - | - | 5.9 | pKi | 1250 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of human HDAC7 | B | 5.9 | pKi | 1250 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC7 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 5.9 | pKi | 1250 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC7 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC7 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Activity of human HDAC8 | B | 9.82 | pKi | 0.15 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC8 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 9.82 | pKi | 0.15 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| ChEMBL | Inhibition of recombinant human HDAC8 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC8 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
| ChEMBL | Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2015) 23: 6785-6793 [PMID:26481659] |
| histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] | ||||||||
| ChEMBL | Inhibition of human HDAC9 | B | 5.96 | pKi | 1100 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC9 enzyme using Ac-LeuGlyLys (tfa)-AMC as substrate after 15 to 30 mins | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2013) 56: 6512-6520 [PMID:23865683] |
| GtoPdb | - | - | 5.96 | pKi | 1100 | nM | Ki | Nat Chem Biol (2010) 6: 238-243 [PMID:20139990] |
| ChEMBL | Inhibition of recombinant human HDAC9 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Nat Prod (2011) 74: 2031-2038 [PMID:21793558] |
| ChEMBL | Inhibition of recombinant human HDAC9 after 60 mins by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7672-7680 [PMID:26331334] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
