Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL325439 (Bepafant, WEB-2170) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Platelet activating factor receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5136] [UniProtKB: P21556] | ||||||||
ChEMBL | Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand | F | 7.53 | pKi | 29.2 | nM | Ki | J Med Chem (1994) 37: 2011-2032 [PMID:8027984] |
ChEMBL | In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 3524-3535 [PMID:7658439] |
ChEMBL | Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets. | F | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 3514-3523 [PMID:7658438] |
PAF receptor in Human [GtoPdb: 334] [UniProtKB: P25105] | ||||||||
GtoPdb | - | - | 6.49 | pIC50 | 320 | nM | IC50 | J Pharmacol Exp Ther (1990) 255: 962-8 [PMID:2262914] |
GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | J Pharmacol Exp Ther (1990) 255: 34-9 [PMID:2170626] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]