TPI 1361-17 [Ligand Id: 1315] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2147477
  • MCH1 receptor in Human [GtoPdb: 280] [UniProtKB: Q99705]
  • MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MCH1 receptor in Human [GtoPdb: 280] [UniProtKB: Q99705]
GtoPdb - - 8.2 pIC50 - - - Eur J Pharmacol (2009) 602: 194-202 [PMID:19041642]
MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639]
ChEMBL Antagonist activity at rat MCH1 receptor expressed in HEK 293T cells assessed as inhibition of MCH-induced Ca2+ mobilization after 10 mins by FLIPR assay F 8.21 pIC50 6.1 nM IC50 Bioorg Med Chem Lett (2012) 22: 6039-6047 [PMID:22954736]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]