ChEMBL ligand: CHEMBL193482 (16.alpha.,17.beta.-estriol, 16.ALPHA.-HYDROXYESTRADIOL, Aacifemine, Colpogyn, Estriol, Estriol acetate benzoate, Estriol propionate, Estriol succinate, Gynest, Incurin, NSC-12169, Oestriol, Ortho-gynest, Ovestin, Trihydroxyestrin)
synuclein alpha/Alpha-synuclein in Human [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] There should be some charts here, you may need to enable JavaScript!
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] There should be some charts here, you may need to enable JavaScript!
Lanosterol 14-alpha demethylase in Mycobacterium tuberculosis [ChEMBL: CHEMBL5090] [UniProtKB: P9WPP9] There should be some charts here, you may need to enable JavaScript!
Olfactory receptor 51E2 in Human [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840]
ChEMBL	Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay	B	4.7	pIC50	20100	nM	IC50	Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.06	pIC50	8635	nM	IC50	DrugMatrix in vitro pharmacology data
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	4	pKd	4	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5	pKi	10000	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb	-	-	8.67	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	9.32	pKi	0.48	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	8.77	pIC50	1.69	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay	B	8.7	pEC50	2	nM	EC50	Medchemcomm (2013) 4: 1439-1442
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
GtoPdb	-	-	8.4	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	Agonist activity at ER-beta (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay	B	9.9	pEC50	0.13	nM	EC50	Medchemcomm (2013) 4: 1439-1442
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	4.75	pKi	17884	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	4.41	pIC50	39345	nM	IC50	DrugMatrix in vitro pharmacology data
Lanosterol 14-alpha demethylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5090] [UniProtKB: P9WPP9]
ChEMBL	Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 substrate binding site expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method	B	4	pKd	100000	nM	Kd	Antimicrob Agents Chemother (2007) 51: 3915-3923 [PMID:17846131]
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255]
ChEMBL	Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay	F	4.28	pEC50	53000	nM	EC50	US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (2018)
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.26	pKi	5491	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	4.99	pIC50	10336	nM	IC50	DrugMatrix in vitro pharmacology data
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	5.01	pKi	9800	nM	Ki	Am J Physiol (1996) 270: F326-F331 [PMID:8779894]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	5.63	pKd	5.63	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	6.63	pKd	234.42	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]