ChEMBL ligand: CHEMBL193482 (16.ALPHA.-HYDROXYESTRADIOL, Estriol succinate, Ortho-gynest, Gynest, NSC-12169, Ovestin, Estriol propionate, Estriol, Oestriol, Theelol, Estriol acetate benzoate)
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] There should be some charts here, you may need to enable JavaScript!
Lanosterol 14-alpha demethylase in Mycobacterium tuberculosis [ChEMBL: CHEMBL5090] [UniProtKB: P9WPP9] There should be some charts here, you may need to enable JavaScript!
Olfactory receptor 51E2 in Human [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.06	pIC50	8635	nM	IC50	DrugMatrix in vitro pharmacology data
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	4	pKd	4	-	-Log Kdiss	J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5	pKi	10000	nM	Ki	J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb	-	-	8.67	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	9.32	pKi	0.48	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol)	B	8.77	pIC50	1.69	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay	B	8.7	pEC50	2	nM	EC50	MedChemComm (2013) 4: 1439-1442
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
GtoPdb	-	-	8.4	pKi	-	-	-	Endocrinology (1997) 138: 863-70 [PMID:9048584]
ChEMBL	Agonist activity at ER-beta (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay	B	9.9	pEC50	0.13	nM	EC50	MedChemComm (2013) 4: 1439-1442
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	4.75	pKi	17884	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	4.41	pIC50	39345	nM	IC50	DrugMatrix in vitro pharmacology data
Lanosterol 14-alpha demethylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5090] [UniProtKB: P9WPP9]
ChEMBL	Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 substrate binding site expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method	B	4	pKd	100000	nM	Kd	Antimicrob. Agents Chemother. (2007) 51: 3915-3923 [PMID:17846131]
Olfactory receptor 51E2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523454] [UniProtKB: Q9H255]
ChEMBL	Agonist activity at PSGR/OR51E2 (unknown origin) expressed in human Hana3A cells co-transfected with CRE-Luc by luciferase reporter gene assay	B	4.28	pEC50	53000	nM	EC50	US-20180116992-A1. Modulators of Prostate-Specific G-Protein Receptor (PSGR/OR51E2) and Methods of Using Same (null)
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.26	pKi	5491	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	4.99	pIC50	10336	nM	IC50	DrugMatrix in vitro pharmacology data
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	5.01	pKi	9800	nM	Ki	Am. J. Physiol. (1996) 270: F326-F331 [PMID:8779894]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	5.63	pKd	5.63	-	-Log Kdiss	J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	6.63	pKd	234.42	nM	Kd	J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]