ChEMBL ligand: CHEMBL173031 (LY-233053, LY-235723)
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL	Tested in vitro for the affinity against NMDA receptor in a cortical wedge assay	B	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (1993) 3: 43-48
ChEMBL	Tested in vitro for the affinity against NMDA receptor by examining its ability to inhibit [3H]-CGS-19,755 binding	B	6.97	pIC50	107	nM	IC50	Bioorg Med Chem Lett (1993) 3: 43-48
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	4.38	pIC50	42000	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	4.41	pIC50	39100	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was evaluated in vitro in a cortical-wedge preparation for the antagonism of N-methyl-D-aspartate-induced responses	F	5.38	pIC50	4200	nM	IC50	J Med Chem (1991) 34: 90-97 [PMID:1825117]
ChEMBL	Compound was tested in vitro for its ability to inhibit depolarizations induced by 40 uM NMDA in a cortical slice (NMDA antagonist)	F	5.38	pIC50	4200	nM	IC50	Bioorg Med Chem Lett (1998) 8: 389-394 [PMID:9871691]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	5.62	pIC50	2393	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested for the antagonistic activity against depolarizations due to NMDA using rat cortical slice preparation	F	5.72	pIC50	1900	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	6.97	pIC50	107	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	In vitro binding affinity against N-methyl-D-aspartate glutamate receptor using [3H]CGS-19,755 ligand	B	6.97	pIC50	107	nM	IC50	J Med Chem (1991) 34: 90-97 [PMID:1825117]
ChEMBL	In vitro compound's ability to displace [3H]-CGS-19,755 binding as a measure of its affinity for the glutamate recognition site on the NMDA receptor complex.	B	6.97	pIC50	107	nM	IC50	J Med Chem (1992) 35: 3547-3560 [PMID:1404235]
ChEMBL	Ability to inhibit [3H]-CGS- 19755 binding to NMDA receptor	B	7.17	pIC50	67	nM	IC50	J Med Chem (1992) 35: 3111-3115 [PMID:1387167]
ChEMBL	Compound was tested in vitro for inhibition of binding of [3H]-CGS- 19755 radioligand to NMDA receptor in rat brain membranes	B	7.77	pIC50	17	nM	IC50	Bioorg Med Chem Lett (1998) 8: 389-394 [PMID:9871691]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]