ChEMBL ligand: CHEMBL155333 (KN-93)
cAMP-dependent protein kinase A in Bovine [ChEMBL: CHEMBL2111446] [UniProtKB: P00515, P00517, P05131, P31322] There should be some charts here, you may need to enable JavaScript!
Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799] There should be some charts here, you may need to enable JavaScript!
calcium/calmodulin-dependent protein kinase II alpha subunit in Mouse [GtoPdb: 1555] [UniProtKB: P11798] calcium/calmodulin-dependent protein kinase II alpha subunit in Rat [GtoPdb: 1555] [UniProtKB: P11275] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cAMP-dependent protein kinase A in Bovine (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111446] [UniProtKB: P00515, P00517, P05131, P31322]
ChEMBL	Inhibition of Protein kinase A (PKA) activity, Enzyme assay was done using gamma-[32P]ATP and synthetic peptide substrates	B	4	pIC50	>100000	nM	IC50	J Med Chem (2002) 45: 563-566 [PMID:11806708]
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL	Inhibition of Myosin Light Chain kinase (MLCK)	B	5.01	pIC50	9800	nM	IC50	J Med Chem (2002) 45: 563-566 [PMID:11806708]
calcium/calmodulin-dependent protein kinase II alpha subunit in Mouse [GtoPdb: 1555] [UniProtKB: P11798]
GtoPdb	Assayed using purified mouse CaMKiiα subunit (Komiya et al, 2011).	-	6.43	pIC50	370	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1456-8 [PMID:21292482]; Biochem Biophys Res Commun (1991) 181: 968-75 [PMID:1662507]
calcium/calmodulin-dependent protein kinase II alpha subunit in Rat [GtoPdb: 1555] [UniProtKB: P11275]
GtoPdb	Assay performed using a truncated, recombinant rat CAMKIIalpha subunit, expressed in and purified from Sf9 cells.	-	5.08	pIC50	8400	nM	IC50	J Med Chem (2002) 31: 563-6 [PMID:11806708]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]