ChEMBL ligand: CHEMBL897 (Benemid, Benuryl, HC 5006, NSC-18786, P-(dipropylsulfamoyl)benzoic acid, Probalan, Probampicin, Probecid, Probenate, Probenecid, Probenecidum)
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] ABCC2/Canalicular multispecific organic anion transporter 1 in Rat [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 4/Solute carrier family 22 member 11 in Human [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0] There should be some charts here, you may need to enable JavaScript!
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37] There should be some charts here, you may need to enable JavaScript!
OAT6/Solute carrier family 22 member 20 in Mouse [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69] Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913] There should be some charts here, you may need to enable JavaScript!
UDP-glucuronosyltransferase 1-7 in Human [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7] There should be some charts here, you may need to enable JavaScript!
TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
TAS2R16 in Human [GtoPdb: 669] [UniProtKB: Q9NYV7] There should be some charts here, you may need to enable JavaScript!
TAS2R38 in Human [GtoPdb: 682] [UniProtKB: P59533] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles	F	4.37	pKi	42200	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
ABCC2/Canalicular multispecific organic anion transporter 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073676] [GtoPdb: 780] [UniProtKB: Q63120]
ChEMBL	TP_TRANSPORTER: inhibition of DNP-SG uptake in blie canalicular membrane vesicle from SD rat	F	4.35	pKi	44600	nM	Ki	Drug Metabol Pharmacokin (2002) 17: 23-33 [PMID:15618649]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.37	pKi	431	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.44	pKi	360	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay	B	5.9	pKi	1245	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in OAT4-expressing S2 cells	F	4.26	pKi	54900	nM	Ki	J Pharmacol Exp Ther (2002) 301: 797-802 [PMID:12023506]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT4-expressing S2 cells	F	4.35	pKi	44400	nM	Ki	Biochim Biophys Acta (2002) 1590: 64-75 [PMID:12063169]
ChEMBL	Inhibition of OAT4 (unknown origin)	B	4.26	pIC50	54900	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT4-expressing S2 cells	F	4.6	pIC50	25400	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
ChEMBL	Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation counting	B	4.06	pIC50	86390	nM	IC50	J Med Chem (2011) 54: 2701-2713 [PMID:21449597]
ChEMBL	Inhibition of human URAT1-mediated urate uptake in HEK293 cells	B	4.3	pIC50	50000	nM	IC50	Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024]
ChEMBL	Inhibition of URAT1 (unknown origin)	B	4.82	pIC50	15000	nM	IC50	Medchemcomm (2016) 7: 1587-1595
OAT6/Solute carrier family 22 member 20 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5269] [GtoPdb: 1037] [UniProtKB: Q80UJ1]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.07	pKi	8511.38	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr	B	5.08	pKi	8400	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells	F	4.92	pKi	12100	nM	Ki	Eur J Pharmacol (2001) 419: 113-120 [PMID:11426832]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cells	F	5.36	pKi	4410	nM	Ki	Life Sci (2001) 69: 2123-2135 [PMID:11669456]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing CHO cells	F	5.37	pKi	4300	nM	Ki	Anal Biochem (2000) 283: 49-55 [PMID:10929807]
GtoPdb	-	-	4.9	pIC50	12500	nM	IC50	Kidney Int (2003) 63: 143-55 [PMID:12472777]
ChEMBL	TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cells	F	4.9	pIC50	12500	nM	IC50	Kidney Int (2003) 63: 143-155 [PMID:12472777]
ChEMBL	TP_TRANSPORTER: inhibition of PHA uptake (PHA: 5uM) in hOAT1-expressing S2 cells	F	4.91	pIC50	12300	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
ChEMBL	Inhibition of OAT1 (unknown origin)	B	4.92	pIC50	12100	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells	F	5.13	pIC50	7400	nM	IC50	J Pharmacol Exp Ther (2000) 295: 10-15 [PMID:10991954]
ChEMBL	TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells	F	5.2	pIC50	6300	nM	IC50	Anal Biochem (2000) 283: 49-55 [PMID:10929807]
Organic anion transporter 1/Solute carrier family 22 member 6 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5653] [GtoPdb: 1025] [UniProtKB: Q8VC69]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.19	pKi	6400	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
ChEMBL	Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr	B	5.2	pKi	6309.57	nM	Ki	J Biol Chem (2007) 282: 23841-23853 [PMID:17553798]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cells	F	4.51	pKi	31000	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes	F	4.8	pKi	15800	nM	Ki	Eur J Pharmacol (2000) 409: 31-36 [PMID:11099697]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells	F	4.53	pKi	29800	nM	Ki	J Pharmacol Exp Ther (2002) 302: 666-671 [PMID:12130730]
ChEMBL	TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells	F	5.05	pKi	9000	nM	Ki	Eur J Pharmacol (2001) 419: 113-120 [PMID:11426832]
ChEMBL	TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells	F	5.36	pKi	4410	nM	Ki	Life Sci (2001) 69: 2123-2135 [PMID:11669456]
ChEMBL	Inhibition of OAT3 (unknown origin)	B	5.05	pIC50	9000	nM	IC50	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in hOAT3-expressing S2 cells	F	5.31	pIC50	4930	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oat3-expressing LLC-PK1 cells	F	4.7	pKi	20000	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
ChEMBL	TP_TRANSPORTER: inhibition of PCG uptake in Oat3-expressing LLC-PK1 cells	F	5.35	pKi	4430	nM	Ki	Mol Pharmacol (2002) 61: 982-988 [PMID:11961115]
ChEMBL	TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells	F	5.22	pIC50	6030	nM	IC50	J Pharmacol Sci (2004) 94: 197-202 [PMID:14978359]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells	F	4.13	pKi	74400	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp2-expressing LLC-PK1 cells	F	4.14	pKi	72900	nM	Ki	J Pharmacol Exp Ther (2001) 298: 316-322 [PMID:11408557]
UDP-glucuronosyltransferase 1-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7]
ChEMBL	Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A7	B	4.02	pKi	96000	nM	Ki	Pharmacol Ther (2005) 106: 97-132 [PMID:15781124]
TRPV2 in Rat [GtoPdb: 508] [UniProtKB: Q9WUD2]
GtoPdb	-	-	4.5	pEC50	31900	nM	EC50	Neurosci Lett (2007) 425: 120-5 [PMID:17850966]
TAS2R16 in Human [GtoPdb: 669] [UniProtKB: Q9NYV7]
GtoPdb	-	-	3.53	pIC50	292000	nM	IC50	PLoS One (2011) 6: e20123 [PMID:21629661]
TAS2R38 in Human [GtoPdb: 682] [UniProtKB: P59533]
GtoPdb	-	-	3.68	pIC50	211000	nM	IC50	PLoS One (2011) 6: e20123 [PMID:21629661]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]