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ChEMBL ligand: CHEMBL74975 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
GtoPdb | - | - | 5.6 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. | B | 5.61 | pKi | 2480 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. | B | 4.94 | pKi | 11500 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271] | ||||||||
ChEMBL | Inhibition of human TNKS1 (1030 to 1317) using NAD+ as substrate by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2013) 56: 7880-7889 [PMID:24116873] |
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 4.6 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]