PCCG-4 [Ligand Id: 3335] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL39573 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Concentration required for the half-maximal inhibition of cAMP hydrolysis in BHK cells expressing mGluR2 | F | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1996) 39: 2259-2269 [PMID:8667369] |
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
| ChEMBL | Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells. | B | 5 | pIC50 | 9900 | nM | IC50 | J Med Chem (1999) 42: 1546-1555 [PMID:10229625] |
| GtoPdb | - | - | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1996) 39: 2259-69 [PMID:8667369] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Binding affinity towards metabotropic glutamate receptor mGluR4a | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (1996) 39: 2259-2269 [PMID:8667369] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
