ChEMBL ligand: CHEMBL304858
lanosterol synthase/Lanosterol synthase in Human [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] There should be some charts here, you may need to enable JavaScript!
Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) [ChEMBL: CHEMBL3569] [UniProtKB: P33247] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449]
ChEMBL	Inhibition of oxidosqualene cyclase	B	6.65	pIC50	223.87	nM	IC50	Eur J Med Chem (2008) 43: 1462-1468 [PMID:17981368]
ChEMBL	Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR method	B	8.12	pIC50	7.5	nM	IC50	J Med Chem (2018) 61: 5047-5053 [PMID:29771525]
ChEMBL	Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes	B	8.19	pIC50	6.5	nM	IC50	J Med Chem (2003) 46: 2083-2092 [PMID:12747780]
ChEMBL	Inhibition of oxidosqualene cyclase	B	8.19	pIC50	6.46	nM	IC50	J Med Chem (2007) 50: 5039-5042 [PMID:17760433]
GtoPdb	-	-	8.24	pIC50	5.7	nM	IC50	J Med Chem (2012) 55: 4990-5002 [PMID:22533316]
Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3569] [UniProtKB: P33247]
ChEMBL	Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius	B	7.22	pIC50	60	nM	IC50	J Med Chem (2003) 46: 2083-2092 [PMID:12747780]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]