4-hydroxynonenal [Ligand Id: 6274] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL454280 (4-Hydroxynonenal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2284] [UniProtKB: P04406] | ||||||||
| ChEMBL | Inhibition of GAPDH (unknown origin) measured after 1 hr | B | 4.3 | pIC50 | 50000 | nM | IC50 | Eur J Med Chem (2020) 207: 112740-112740 [PMID:32898762] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86] | ||||||||
| ChEMBL | Activation of TRPA1 channel in rat dorsal root ganglion neurons assessed as increase in intracellular calcium level | B | 4.11 | pEC50 | 77000 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 13519-13524 [PMID:17684094] |
| ChEMBL | Agonist activity at rat TRPA1 channel expressed in tetracycline induced HEK293 cells assessed as increase in intracellular calcium | F | 4.57 | pEC50 | 27000 | nM | EC50 | Proc Natl Acad Sci U S A (2007) 104: 13519-13524 [PMID:17684094] |
| ChEMBL | Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx | F | 4.57 | pEC50 | 27000 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| GtoPdb | Calcium imaging | - | 4.6 | pEC50 | - | - | EC50 |
Proc Natl Acad Sci USA (2007) 104: 13519-24 [PMID:17684094]; J Neurosci (2007) 27: 11412-5 [PMID:17942735] |
| ChEMBL | Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influx | F | 4.7 | pEC50 | 19900 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
