4-hydroxynonenal [Ligand Id: 6274] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL454280 (4-Hydroxynonenal)
  • TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86]
ChEMBL Activation of TRPA1 channel in rat dorsal root ganglion neurons assessed as increase in intracellular calcium level B 4.11 pEC50 77000 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 13519-13524 [PMID:17684094]
ChEMBL Agonist activity at rat TRPA1 channel expressed in tetracycline induced HEK293 cells assessed as increase in intracellular calcium F 4.57 pEC50 27000 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 13519-13524 [PMID:17684094]
ChEMBL Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx F 4.57 pEC50 27000 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]
GtoPdb Calcium imaging - 4.6 pEC50 - - EC50 Proc Natl Acad Sci USA (2007) 104: 13519-24 [PMID:17684094];
J Neurosci (2007) 27: 11412-5 [PMID:17942735]
ChEMBL Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influx F 4.7 pEC50 19900 nM EC50 J. Med. Chem. (2010) 53: 5085-5107 [PMID:20356305]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]