lanosterol [Ligand Id: 2746] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL225111 (Lanostereol)
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  • Farnesoid X receptor-β in Mouse [GtoPdb: 604]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Alpha-crystallin B chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621022] [UniProtKB: P02511]
ChEMBL Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cells incubated for 6 to 8 hrs by fluorescence microscopy relative to untreated control B 5.85 pEC50 1420 nM EC50 J Med Chem (2018) 61: 8693-8706 [PMID:30153006]
Farnesoid X receptor-β in Mouse [GtoPdb: 604]
GtoPdb - - 6 pEC50 - - - Mol Cell Biol (2003) 23: 864-72 [PMID:12529392]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]