Synonyms: EIDD-1931 | NHC
Compound class:
Synthetic organic
Comment: Preliminary evidence indicates that the ribonucleoside analogue β-D-N4-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs [1]. The potency of the NHC ester prodrug (molnupiravir) against multiple coronaviruses, its therapeutic efficacy, and oral bioavailability in vivo, all highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses.
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Classification ![]() |
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Compound class | Synthetic organic |
Prodrug | molnupiravir |
IUPAC Name ![]() |
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one |
Synonyms ![]() |
EIDD-1931 | NHC |
Database Links ![]() |
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CAS Registry No. | 3258-02-4 |
ChEMBL Ligand | CHEMBL2178720 |
GtoPdb PubChem SID | 405067328 |
PubChem CID | 197020 |
RCSB PDB Ligand | U56 |
Search Google for chemical match using the InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N |
Search Google for chemicals with the same backbone | XCUAIINAJCDIPM |
UniChem Compound Search for chemical match using the InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N |
UniChem Connectivity Search for chemical match using the InChIKey | XCUAIINAJCDIPM-XVFCMESISA-N |