β-D-N4-hydroxycytidine

Ligand id: 10735

Name: β-D-N4-hydroxycytidine

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 137.07
Molecular weight 259.08
XLogP -0.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
Synonyms
EIDD-1931 | NHC
Comments
Preliminary evidence form a BioRxiv preprint indicates that the ribonucleoside analog β-D-N4-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs. The potency of the NHC ester prodrug (EIDD-2801) against multiple coronaviruses, its therapeutic efficacy, and oral bioavailability in vivo, all highlight its potential utility as an effective antiviral against SARS-CoV-2 and other future zoonotic coronaviruses.
Database Links
CAS Registry No. 3258-02-4
ChEMBL Ligand CHEMBL2178720
GtoPdb PubChem SID 405067328
PubChem CID 197020
Search Google for chemical match using the InChIKey XCUAIINAJCDIPM-XVFCMESISA-N
Search Google for chemicals with the same backbone XCUAIINAJCDIPM
Search UniChem for chemical match using the InChIKey XCUAIINAJCDIPM-XVFCMESISA-N
Search UniChem for chemicals with the same backbone XCUAIINAJCDIPM